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TranscriptomicsTranscription profiling of human lung adneocarcinomas - discovery of somatic mutations in lung adenocarcinomas
This was a collaborative study to discover somatic mutations in 188 lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-12667 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse resting and IL-15 activated natural killer cells
Murine NK cells were compared at rest and following 24 hours of IL-15 stimulation for their mRNA expression profiles on the Affymetrix MOE430_2 microarray platform. Additional comparators included resting bulk splenocytes. Experiment Overall Design: Three pairs of flow sorted murine NK cells (C57Bl...
ORGANISM(S): Mus musculus 
2009-04-28 | E-GEOD-7764 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Naive Treg, allogeneic tumor-activated Treg, and GVHD-activated Treg cells
Regulatory T (Treg) cells play an important role in the induction and maintenance of peripheral tolerance. Treg cells also suppress a variety of other immune responses, including anti-tumor and alloimmune responses. We have previously reported that tumor-activated Treg cells express granzyme B and...
ORGANISM(S): Mus musculus 
2009-09-15 | E-GEOD-16210 | biostudies-arrayexpress
TranscriptomicsAltered levels of MOF and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR).
Full title: Altered levels of MOF (member of MYST family histone acetyl transferase) and decreased levels of H4K16ac correlate with a defective DNA damage response (DDR). The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that altered le...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20193 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.
Extrahepatic cholestasis leads to complex injury and repair processes that result in bile infarct formation, neutrophil infiltration, cholangiocyte and hepatocyte proliferation, extracellular matrix remodeling, and fibrosis. To identify early molecular mechanisms of injury and repair after bile duct...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29776 | biostudies-arrayexpress
TranscriptomicsExpression data from human neutrophils exposed to uropathogenic and commensal Esherichia coli.
The establishment of bacterial infections at epithelial surfaces is determined by the balance of virulence attributes of the pathogen with the activity of innate host defenses. Polymorphonuclear leukocytes (PMN) are key responders in many bacterial infections, but the mechanisms by which pathogens ...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-18810 | biostudies-arrayexpress
TranscriptomicsWhole genome sequencing of murine induced Pluripotent Stem (iPS) cell clones
Whole genome sequencing was performed on several murine iPS cell clones (and their parental cells) from each of three independent reprogramming experiments. Hundreds of single nucleotide variants (SNVs) were detected in each clone, with an average of 11 in coding regions. Affymetrix Mouse Exon 1.0ST...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-36017 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are a heterogenous group of hematopoietic stem cell disorders characterized by dysplastic blood cell formation and peripheral blood cytopenias. Up to 30% of patients with MDS will progress to a highly chemotherapy-resistant secondary acute myeloid leukemia (sAML). W...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-30195 | biostudies-arrayexpress
UnknownEfficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study.
Not available
S-EPMC10626161 | biostudies-literature
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