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MetabolomicsMFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis

Hemolysis drives susceptibility to lung injury and predicts poor outcomes in diseases, such as malaria and sickle cell disease (SCD). However, the underlying pathological mechanism remains unknown. Here, we report that major facilitator superfamily domain containing 7C (MFSD7C) protects the lung ...

2024-09-06 | MTBLS9293 | MetaboLights
ProteomicsMurine alveolar macrophage cell line MH-S was transduced with lentivirus expressing GFP alone or GFP plus murine MFSD7C tagged with Myc and FLAG epitopes.
We used immunoprecipitation (IP) and mass spectrometry (MS) to identify proteins that interact with MFSD7C. Because an anti-MFSD7C monoclonal antibody is not available, we used MFSD7C tagged with both Myc and FLAG epitopes in a MFSD7C-expressing murine alveolar macrophage cell line MH-S (Supplementa...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-20 | PXD021016 | Pride
Lc-msms Mfsd7c Alveolar macropahge Murine 
GenomicsMFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis
MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis
PRJNA1062043 | ENA
GenomicsTranscriptomic analysis of Wild-type and Mfsd7c-/-knockout brain embryos
Transcriptomic analysis of Wild-type and Mfsd7c-/-knockout brain embryos
PRJNA625965 | ENA
TranscriptomicsTranscriptomic analysis of Wild-type and Mfsd7c-/-knockout brain embryos
Mfsd7c is expressed in CNS blood vessels. Deletion of Mfsd7c results in embryonic lethality with signs of hypoxia. We performed transcriptomic analysis of genes in brains of E14.5 wild-type (WT) and Mfsd7c-knockout (KO) embryos.
ORGANISM(S): Mus musculus 
2020-05-18 | GSE148854 | GEO
UnknownMFSD7c functions as a transporter of choline at the blood-brain barrier.
Not available
S-EPMC10907603 | biostudies-literature
UnknownDeficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome.
Not available
S-EPMC7410059 | biostudies-literature
UnknownMFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.
Not available
S-EPMC11413235 | biostudies-literature
TranscriptomicsMFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis
Hemolysis drives susceptibility to lung injury and predicts poor outcomes in diseases, such as malaria and sickle cell disease (SCD). However, the underlying pathological mechanism remains unknown. Here, we report that major facilitator superfamily domain containing 7C (MFSD7C) protects the lung fro...
ORGANISM(S): Homo sapiens 
2024-02-08 | GSE252686 | GEO
TranscriptomicsMajor Facilitator Superfamily Domain Containing 7C (Mfsd7c) Mediates the Effects of Heme on Cell Metabolism, Motility and Transcription
Dysfunctional mutations of major facilitator superfamily domain containing 7C (Mfsd7c) are associated with Fowler's Syndrome. However, beyond its reported activity in heme importation, the function of Mfsd7c is unknown. Herein, we show that Mfsd7c forms complexes with proteins in both mitochondrial ...
ORGANISM(S): Mus musculus 
2018-06-08 | GSE83125 | GEO
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