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ProteomicsStudy Samples Dendritic Cell MHC II presentation by LC-MSMS
MAPPs data was used to construct an artificial neural network (ANN) model for MHC class II antigen presentation. Using Infliximab and Rituximab, the model demonstrated an unprecedented performance for predicting MAPPs and CD4 T cell epitopes, complementing results from MAPPs assays and outperforming...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD018303 | Pride
Lc-msms Mhc-associated peptide proteomics (mapps) Mhc ii presentation Dendritic cells 
ProteomicsIdentification of MHC ligands through allele guided isolation combined with machine learning for specific MHC assignment
Isolation of MHC ligands and subsequent analysis by mass spectrometry is considered the gold standard for defining targets for T cell-based immunotherapies. However, as many targets of high tumor-specificity are only presented at low abundance on the cell surface of tumor cells, the efficient isolat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD061101 | Pride
Hla assignment Machine learning Immunopeptidome 
ProteomicsMapping the peptide binding groove of MHC class I
An essential element of adaptive immunity is the selective binding of peptide antigens by major histocompatibility complex (MHC) class I proteins and their presentation to cytotoxic T lymphocytes on the cell surface. Using native mass spectrometry, we here analyze the binding of peptides to an empty...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD027725 | Pride
Peptide-binding Hla-a Native ms Human Mhc class i 
ProteomicsMHC-IP MS of EpiScan A02 SARS-CoV-2 library
Identification of CD8+ T-cell epitopes is critical for the development of immunotherapeutics. Existing methods for MHC-I ligand discovery are time-intensive, specialized and unable to interrogate specific proteins on a large scale. Here we present EpiScan, which uses surface MHC-I levels as a readou...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2022-10-13 | PXD036939 | Pride
Episcan mhc-ip sars-cov-2 hla-a*02:01 
UnknownQuantification of Uncertainty in Peptide-MHC Binding Prediction Improves High-Affinity Peptide Selection for Therapeutic Design.
Not available
S-EPMC6715517 | biostudies-literature
UnknownStructure-aware deep model for MHC-II peptide binding affinity prediction.
Not available
S-EPMC10826266 | biostudies-literature
UnknownRPEMHC: improved prediction of MHC-peptide binding affinity by a deep learning approach based on residue-residue pair encoding.
Not available
S-EPMC10796178 | biostudies-literature
ProteomicsTargeted delivery of tumor necrosis factor in combination with lomustine induces a T-cell dependent regression of glioblastoma
Glioblastoma is the most aggressive primary brain tumor with an unmet need for more effective therapies. Here we report that the combination of L19TNF, an antibody-cytokine fusion protein based on tumor necrosis factor that selectively localizes on the tumor neo-vasculature, with the alkylating ag...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-01 | PXD041256 | Pride
Immunotherapy mhc-i Immunopeptidomics 
UnknownPrediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method.
Not available
S-EPMC1939856 | biostudies-literature
ProteomicsNNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T cell epitope predictions
Current mass spectrometry technologies allow for identification of MHC-associated peptide ligands. Studies have proven these data to be a rich source of information for learning the rules of MHC-mediated antigen presentation. Such immunopeptidomes are usually poly-specific, containing multiple seque...
ORGANISM(S): Bos taurus (Bovine) 
2019-10-07 | PXD015240 | Pride
Immunopeptidomics Bola ligandome 
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