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GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
EGAS00001005060 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
ProteomicsQuantitative cell type specific immunopeptidome analysis during macrophage and tumor co-evolution reveals therapeutic MHC-I restricted peptides in glioblastoma
Glioblastoma treatment by immunotherapy is limited by the immunosuppresive tumor microenvironment, in part created by GBM associated macrophages. To uncover targetable MHC-I peptides for targeted immunotherapy, we performed cell type specific immunopeptidome analysis on primary macrophages and GBM t...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-03 | PXD057588 | Pride
Tumor associated macrophage Mhc-i restricted peptides Glioblastoma Immunopeptidome 
ProteomicsExtending the Mass Spectrometry-Detectable Landscape of the Immunopeptidome by use of Restricted access Material
Mass spectrometry-based immunopeptidomics enables the comprehensive identification of major histocompatibility complex (MHC) peptides from cell culture as well as from tissue or tumor samples and is increasingly applied for the identification of tumor-specific and viral T-cell epitopes. Although mas...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-07 | PXD034017 | Pride
Immunopeptidomics Solid phase extraction Restricted access material 
ProteomicsMHC I-restricted immunopeptidomics analysis of human monocyte-derived macrophages exposed to biological nanoparticles bearing influenza hemagglutinin
In this study, primary human monocyte-derived macrophages were exposed to plant-derived virus-like particles (VLPs) bearing influenza A hemagglutinin (HA) or soluble influenza HA, as control. Immunopurified MHC class I-associated peptides were analysed by nano-flow high pressure liquid chromatograph...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD010741 | Pride
Proteomics Human antigenic peptides Dopant-assisted electrospray ionisation (da-esi) Immunopeptidomics High-resolution mass spectrometry Class i major histocompatibility complex (mhc) Virus-like particle (vlp) Monocyte-derived macrophage (mdm) 
GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
PRJNA701479 | ENA
TranscriptomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
ORGANISM(S): Homo sapiens 
2021-03-03 | GSE166651 | GEO
Genomics5a9f4bd6-d795-47e9-9690-979bf5b1df6b - samples
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the samp...
EGAD00001006995 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
ProteomicsLC-MSMS of the lc4 MHC class I immunopeptidome
MHC I-associated peptides (MAPs) presented at the surface of nucleated cells play a central role in CD8 T-cell immunosurveillance. MAPs presented by mature (i.e. MHC IIhi) medullary thymic epithelial cells (mTEChi) are essential to eliminate self-reactive CD8 T cells in a process called central tole...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD009754 | Pride
Human Lc-msms Immunopeptidome Lung cancer primary sample Mhc class i 
ProteomicsLC-MSMS of the lc6 MHC class I immunopeptidome
MHC I-associated peptides (MAPs) presented at the surface of nucleated cells play a central role in CD8 T-cell immunosurveillance. MAPs presented by mature (i.e. MHC IIhi) medullary thymic epithelial cells (mTEChi) are essential to eliminate self-reactive CD8 T cells in a process called central tole...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD009755 | Pride
Human Lc-msms Immunopeptidome Lung cancer primary sample Mhc class i 
ProteomicsLC-MSMS of the lc2 MHC class I immunopeptidome
MHC I-associated peptides (MAPs) presented at the surface of nucleated cells play a central role in CD8 T-cell immunosurveillance. MAPs presented by mature (i.e. MHC IIhi) medullary thymic epithelial cells (mTEChi) are essential to eliminate self-reactive CD8 T cells in a process called central tole...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD009752 | Pride
Human Lc-msms Immunopeptidome Lung cancer primary sample Mhc class i 
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