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GenomicsPseudomonas aeruginosa strain:MIB-1 | isolate:MIB-1
Pseudomonas aeruginosa strain:MIB-1 | isolate:MIB-1 Genome sequencing
PRJNA1334320 | ENA
TranscriptomicsRNA from 3 d and 2 d old embryos of mibta52b, mibm132 and mibtfi91, and RNA from 3 d, 2d and 1 d old embryos of mibta52b
The Notch signaling is an evolutionarily conserved signal transduction cascade that plays essential roles in a variety of developmental processes. In this study, we examined the mib mutants for defects in pancreas development using in situ hybridization and GFP expression analysis of pancreas-specif...
ORGANISM(S): Danio rerio 
2010-06-25 | E-GEOD-8522 | biostudies-arrayexpress
ProteomicsUse of a modified Multiplexed Inhibitor Bead assay to study kinome responses to cytostatic treatment in human cancer cell lines Triplicate Test: pilot study
In order to improve elution of proteins from the column, to reduce the cost as well as the hands on time of the analysis, we here present a modification of the Multiplexed Inhibitor Bead assay (MIB assay), where we elute the proteins from beads containing covalently bound inhibitors using trypsin di...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080744 | MassIVE
ProteomicsDetermining MELK inhibitor specificity using MIB/MS
The key objectives of this study were to evaluate the selectivity profiles of three MELK inhibitors, 8a, HTH, and OTS, using a cell-based assay, in order to identify a highly selective inhibitor to subsequently investigate MELK function. To this end, we utilized a chemical proteomics approach called...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016022 | Pride
Chemoproteomics Lfq Kinase enrichment 
ProteomicsMIB-MS analysis of MERS-CoV and SARS-COV-2 infected cells.
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated coronaviruses specifically target kinase cascades to subvert host cell responses to infection and rely upon host kinase activity...
ORGANISM(S): Homo sapiens (Human) 
2023-08-01 | PXD040901 | Pride
Mib-ms  kinases  kinome  coronavirus  mers-cov  sars-cov-2  lfq quantitation  dda  lc-ms/ms. 
Genomicslake water metagenome
MIB cyclase gene amplicon sequencing
PRJDB8900 | ENA
ProteomicsMIB/MS determines SCH772984 is a selective ERK1/2 inhibitor in pancreatic cancer cells
Mutational activation of the KRAS oncogene is a major genetic driver of pancreatic ductal adenocarcinoma (PDAC) growth. KRAS-dependent PDAC growth is mediated primarily through persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade, one of the most extensively studi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD043585 | Pride
Erk Mib/ms Kinases Pancreatic cancer 
UnknownA new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect.
Not available
S-EPMC4454137 | biostudies-literature
ProteomicsThe MICOS-MIB complex member PERM1 connects mitochondria with the sarcolemma via ankyrin B
Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profili...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-16 | PXD025745 | Pride
Mitochondria  skeletal muscle  perm1  proteomics 
Unknown2-Methylisoborneol (2-MIB) Excretion by Pseudanabaena yagii under Low Temperature.
Not available
S-EPMC8705757 | biostudies-literature
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