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TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of light and carbon signaling interactions in Arabidopsis
A. thaliana seeds of Columbia (Col-0) ecotype were surface-sterilized, plated on designated media and vernalized for 48 hours at 8C. Plants were grown semi-hydroponically under 16-hr-light, 8-hr-dark cycles at a constant temperature of 23C on basal Murashige and Skoog medium supplemented with 2 mM K...
ORGANISM(S): Arabidopsis thaliana 
2004-01-23 | E-MEXP-71 | biostudies-arrayexpress
TranscriptomicsComparison of transcription profiles of C. neoformans during rabbit or human infection
Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degrada...
ORGANISM(S): Cryptococcus neoformans 
2012-04-10 | E-GEOD-36183 | biostudies-arrayexpress
TranscriptomicsComparison of transcription profiles for C. neoformans during rabbit infection
Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degrada...
ORGANISM(S): Cryptococcus neoformans 
2012-04-10 | E-GEOD-36182 | biostudies-arrayexpress
ProteomicsPredictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network
The Epidermal Growth Factor Receptor (EGFR) has been studied extensively due to its critical role in cellular signaling and association with disease. Previous models have elucidated interactions between EGFR and downstream adaptor proteins, or showed phenotypes affected by EGFR. However, the link be...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-09 | PXD032403 | Pride
Egfr phosphoproteomics phosphorylation signaling tyrosine 
TranscriptomicsTranscriptome signature of white adipose tissue, liver, and skeletal muscle in 24 hours fasted mice (C57Bl/6J)
Fasting is the process of metabolic adaption to food deprivation that is taking place in most organisms, e.g. during the daily resting phase in mammals. Furthermore, in biomedical research fasting is used in most metabolic studies to synchronize nutritional states of study subjects. Because there is...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-46495 | biostudies-arrayexpress
Methylation profilingThe epigenetic and transcriptional basis of a developmental transition from brown to white adipose tissue
Brown and white adipose tissues are functionally and morphologically distinct. Theformer tissue has a primary role in maintaining thermogenesis in new born mammals while the latter acts as an energy storage vehicle that enhances survival when food is limiting. Both tissues are involved in maintainin...
ORGANISM(S): Ovis aries 
2018-07-01 | GSE70127 | GEO
TranscriptomicsTranscription profiling of mouse white adipose tissue from mice fed trans-10, cis-12 conjugated linoleic acid to determine the processes involved in the generated inflammation and de-lipidation of the adipose tissue
The white adipose tissue (WAT) rapidly loses mass when mice are fed a diet containing trans-10, cis-12 conjugated linoleic acid (t10c12 CLA). A microarray analysis of WAT due to CLA feeding was performed to better define the processes and genes involved.
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4671 | biostudies-arrayexpress
UnknownInterferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Not available
S-EPMC6721795 | biostudies-literature
TranscriptomicsIncreased expression of c-Jun in nonalcoholic fatty liver disease
Background & Aims: Overnutrition is one of the major causes of non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH). Besides the quantity of consumed calories, distinct dietary components are increasingly recognized as important contributor to the path...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-52748 | biostudies-arrayexpress
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