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ProteomicsChemical phosphoproteomics sheds new light on the targets and modes of action of AKT inhibitors
Due to its important roles in oncogenic signaling, AKT has been subject to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials. To better understand how these drugs exert their therapeutic effects at the molecular level, we combined chemopro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD021836 | Pride
Kinobeads Akt inhibitor Phosphoproteomics 
UnknownRFT1 deficiency in three novel CDG patients.
Not available
S-EPMC3869400 | biostudies-literature
UnknownGlycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.
Not available
S-EPMC2871502 | biostudies-literature
UnknownTextbook Outcome After Major Liver Resection for Primary and Secondary Liver Tumors at Specialized German Hepatobiliary Centers: Analysis of the StuDoQ Liver Registry.
Not available
S-EPMC12454482 | biostudies-literature
UnknownIdentifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.
Not available
S-EPMC6546437 | biostudies-literature
UnknownTherapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.
Not available
S-EPMC6960691 | biostudies-literature
ProteomicsEffect of Cpd1 on melanoma proteome
Investigation of the time dependent effect of Cpd1 (small molecule interactor) on the proteome composition of melanoma WM3734 line by label-free quantification using mass spectrometry. The goal was to identify which protein abundances are increased upon treatment with Cpd1. Melanoma cell line WM3734...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD008757 | Pride
Jarid1b Cpd1 Melanoma cell line wm3734 
Unknown[Randomized controlled multicenter study of albumin replacement therapy in septic shock (ARISS)].
Not available
S-EPMC8189957 | biostudies-literature
UnknownManagement of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves.
Not available
S-EPMC5950928 | biostudies-literature
UnknownAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis.
Not available
S-EPMC9398945 | biostudies-literature
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