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MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsQuantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-23 | PXD012089 | Pride
Ethanol metabolism Succinylation Mitochondira Acetylation Acylation 
ProteomicsAcetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
In this manuscript we have explored the role of both Nrf2 and NQO1 in protection against diet-induced metabolic syndrome and demonstrate that both Nrf2 and NQO1 provide protection against HFD-induced adverse phenotypes in a mouse model
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015070 | Pride
Nqo1 Mouse Metabolic syndrome Quantitation Acetylomics Skeletal muscle 
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