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Distinct spatial organization governs oral mucosal immunity
Immune responsiveness at barrier surfaces is tailored to the exposures of each tissue. In the oral mucosa, mechanisms by which a permeable epithelium coexists with diverse microbiota and maintains integrity during inflammatory pathology remain poorly understood. We compile a multi-omics spatial map ...
ORGANISM(S): Homo sapiens 
2025-11-18 | GSE296447 | GEO
This study generated spatial transcriptomic profiles of ileum, cecum, and colon from specific pathogen-free (SPF) and germ-free (GF) Kunming (KM) mice using the BGI Stereo-seq platform. The dataset captures spatial organization and segment-specific immune niches in the absence of microbiota.
ORGANISM(S): Mus musculus 
2026-08-04 | GSE341914 | GEO
Healthy human and mouse colon epithelium is a major source of active thrombin, released in lumen. Using germ-free animals, we demonstrated that mucosal thrombin was directly regulated by the presence of commensal microbiota. Specific inhibition of lumenal thrombin activity caused macro-, microscopic...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD014315 | Pride
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