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ProteomicsProteomic Profiling of Concurrently Isolated Primary Microvascular Endothelial Cells, Pericytes, and Smooth Muscle Cells from Adult Mouse Heart (ALK1571, PSR-OHSU)
The microcirculation serves crucial functions in adult heart that are distinct from those carried out by epicardial vessels. Microvessels are also governed by unique regulatory mechanisms, impairment of which leads to microvessel-specific pathology. While great progress has been made in understandin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD026673 | Pride
Primary culture Vascular smooth muscle cells Mouse heart Pericytes Psr-ohsu Endothelial cells Tmt labeling Microvascular Quantitative proteomics 
TranscriptomicsGene expression during SMC cord morphogenesis
SMCs must undergo specialzed patterning during blood vessel stabilization. We used microarray analysis to identify differentially expressed genes as smooth muscle cells were induced to assemble into a network of elongated cords. Two time points (Day 0 and Day 8) and three biological replicates for e...
ORGANISM(S): Homo sapiens 
2011-04-17 | E-GEOD-21363 | biostudies-arrayexpress
ProteomicsA proteomics resource for human iPSC-derived endothelial cells (iEC), smooth muscle cells (iSMC), pericytes (iPC) and astrocytes (iAS) in comparison to iPSCs and human primary cells - technical replicates
Function and integrity of the blood-brain-barrier (BBB) is crucial for brain homeostasis, and its malfunction critically contributes to neurovascular and neurodegenerative disorders, including cerebral small vessel disease (SVD), a common cause of stroke and vascular dementia. So far, mechanistic st...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD051959 | Pride
Human Astrocytes Ipsc Pericytes Endothelial cells Smooth muscle cells 
ProteomicsBidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR
Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary vascular resistance (CVR), but their mechanisms of action are not fully understood. We identified G protein-coupled receptor 39 (GPR39) as a ...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-13 | PXD013952 | Pride
Proteomics Eicosanoids G-coupled receptor 39 Microvascular smooth muscle cell Cardiovascular disease Photoactive cross-linking 
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue miRNA Expression
miRNA profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells trasduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare miRNA expression in Rap1A -/- mVSMs and '...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24749 | biostudies-arrayexpress
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue mRNA Expression
Transcriptional profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells transduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare mRNA expression in Rap1A -/- mV...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-25190 | biostudies-arrayexpress
TranscriptomicsRap1a GTPase mVSM Knockout vs. Rescue mRNA Expression
Transcriptional profiling of mouse tail artery explanted microvascular smooth muscle (mVSM) cells comparing Rap1a -/- mVSM cells transduced with vector backbone (control) with Rap1a -/- mVSM cells transduced with a Rap1 CA 'rescue' plasmid. The experiment will compare mRNA expression in Rap1A -/- m...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-25702 | biostudies-arrayexpress
GenomicsMicrovascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1
PRJNA1375705 | ENA
ProteomicsA proteomics resource for human iPSC-derived endothelial cells (iEC), smooth muscle cells (iSMC), pericytes (iPC) and astrocytes (iAS) in comparison to human primary cells - technical and biological replicates
Integrity of the blood-brain barrier (BBB) is critical for brain homeostasis, and its malfunction contributes to neurovascular and neurodegenerative disorders. So far, mechanistic studies on BBB function have been mostly conducted in rodent and non-physiological in vitro models, which recapitulate s...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD066414 | Pride
Astrocytes Pericytes Endothelial cells Ipsc Smooth muscle cells Blood-brain barrier 
TranscriptomicsInterference with PPAR gamma signaling in mesenteric artery
Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset h...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-36482 | biostudies-arrayexpress
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