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ProteomicsChronic Midazolam Exposure on Neonates and Long-Term Neurodevelopment
About 1 in 10 U.S. newborns are born preterm and often require sedation, which may pose long-term neurodevelopmental risks. This study examined the effects of chronic exposure to midazolam (MDZ), a sedative commonly used in NICUs, using a rodent model. Researchers assessed physical, molecular, bioch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-27 | PXD062940 | Pride
Midazolam Neurodevelopment 
GenomicsEpigenetic and transcriptomic profiling of neural stem cells after midazolam exposure
Epigenetic and transcriptomic profiling of neural stem cells after midazolam exposure
PRJNA700439 | ENA
TranscriptomicsEpigenetic and transcriptomic profiling of neural stem cells after midazolam exposure
Here we show that early-life exposure to midazolam (MDZ), a widely used drug in pediatric anesthesia, persistently alters chromatin accessibility and expression of quiescence-associated genes in neural stem cells (NSCs) in mouse hippocampus. The alterations led to a continuous restriction of NSC pro...
ORGANISM(S): Mus musculus 
2021-08-29 | GSE166322 | GEO
UnknownDevelopment and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study.
Not available
S-EPMC5662017 | biostudies-literature
UnknownPEGylation of liposome-encapsulated midazolam does not improve the bioavailability of midazolam when administered orally.
Not available
S-EPMC12522756 | biostudies-literature
UnknownRandomized single-blind comparative study of the midazolam/pethidine combination and midazolam alone during bronchoscopy.
Not available
S-EPMC9102220 | biostudies-literature
UnknownNE contribution to rebooting unconsciousness caused by midazolam.
Not available
S-EPMC11578583 | biostudies-literature
UnknownPropofol Alone versus Propofol in Combination with Midazolam for Sedative Endoscopy in Patients with Paradoxical Reactions to Midazolam.
Not available
S-EPMC8995981 | biostudies-literature
UnknownComposite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity.
Not available
S-EPMC7652802 | biostudies-literature
UnknownAllopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats.
Not available
S-EPMC11871396 | biostudies-literature
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