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ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
TranscriptomicsPosterior brain organoids multi-omics atlas
Here, we generated multiome (coupled scRNA-seq and scATAC-seq) data over a time course of mid- and hindbrain organoid development to map cell composition and explore the regulatory mechanisms underlying cell type maturation. The dataset incorporates 5 time points from day 7 to day 120 from 3 human i...
ORGANISM(S): Homo sapiens 
2026-03-17 | E-MTAB-15659 | biostudies-arrayexpress
ProteomicsAn Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry
Patient-derived organoids from induced pluripotent stem cells have emerged as a model for studying human diseases beyond conventional two-dimensional (2D) cell culture. As such, the development of robust methods to study global proteostasis and protein turnover in organoids will remain essential as ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD032169 | Pride
Midbrain organoid Midbrain Silac Half-life determination Turnover D3-leucine Topograph Organoid 
TranscriptomicsTranscriptome profiling of DA neurons, human midbrain-like organoids and prenatal midbrain
Recent advances in three dimensional (3D) culture systems have led to the generation of brain organoids that share resemblance to different parts of the human brains; however, a 3D organoid model of the midbrain that contains functional midbrain dopaminergic (mDA) neurons has not been reported. In t...
ORGANISM(S): Homo sapiens 
2016-08-24 | E-MTAB-4868 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of Human midbrain organoids differentiated from WTSIi018-B-1 (healthy) and EDi001-B (Parkinson's Disease) iPSCs
Day 49 organoid differentiation of midbrain organoids
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-12339 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human midbrain organoid models of Parkinson's Disease
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that is characterized by the selective loss of midbrain dopamine (DA)-producing neurons and the formation of α-synuclein (α-syn)-containing inclusions named Lewy bodies (LBs). Here, we report that the loss of glucocerebrosidase (GCas...
ORGANISM(S): Homo sapiens 
2021-08-13 | E-MTAB-7302 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of posterior brain organoid morphogen screen
To pattern novel posterior brain regions, we used a multiplexed morphogen screen with a single-cell sequencing readout to test 48 concentrations and combinations of 10 morphogens involved in brain patterning. This screen revealed the emergence of regions harboring under-represented cell types, such ...
ORGANISM(S): Homo sapiens 
2026-03-16 | E-MTAB-15660 | biostudies-arrayexpress
GenomicsRNA-seq of human midbrain organoid models of Parkinson's Disease
RNA-seq of human midbrain organoid models of Parkinson's Disease
PRJEB45026 | ENA
GenomicsReproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (timepoints)
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (timepoints)
PRJNA1121199 | ENA
GenomicsReproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (passages)
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling (passages)
PRJNA1213756 | ENA
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