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ProteomicsThe HDAC1/DNTTIP1/Flag-tagged MIDEAS (Tyr654Ser) complex was expressed by transient transfection in HEK293F cells. The complex was purified using anti-flag resin and gel filtration. You from here
Analysis of the phosphorylation state of a mis-sense variant in MIDEAS (Tyr654Ser). The substitution from YTP to STP generates a CDK kinase site that is phosphorylated in a human cell line.
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD064578 | Pride
Human Hdac1 Tdif Histone deacetylase Elmsan1 Dnttip1 Mideas 
ProteomicsA de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome
Analysis of the phosphorylation state of a mis-sense variant in MIDEAS (Tyr654Ser). The substitution from YTP to STP generates a CDK kinase site that is phosphorylated in a human cell line.
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD067661 | Pride
Human Hdac1 Tdif Histone deacetylase Elmsan1 Dnttip1 Mideas 
GenomicsEmbryonic day 13.5 mRNA profiles for wildtype and MIDEAS and DNTTIP1 knockout MEFs
Embryonic day 13.5 mRNA profiles for wildtype and MIDEAS and DNTTIP1 knockout MEFs
PRJNA604774 | ENA
UnknownLong non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Not available
S-EPMC10540452 | biostudies-literature
TranscriptomicsEmbryonic day 13.5 mRNA profiles for wildtype and MIDEAS and DNTTIP1 knockout MEFs
Objective: Perform deep sequencing on mouse embryonic fibroblasts from e13.5 embryos with wildtype, MIDEAS-/- and DNTTIP1-/- genotypes to provide insights into observed embryonic lethality with associated haemolytic anaemia and heart defects. Method: Heterozygous mates of MIDEAS or DNTTIP1 set up an...
ORGANISM(S): Mus musculus 
2020-05-26 | GSE144748 | GEO
UnknownA de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome.
Not available
S-EPMC12647621 | biostudies-literature
GenomicsChIP-Seq mapping of H2AK5ac, H2AK9ac, DNTTIP1, MIDEAS, and LIG4 at AsiSI-induced DNA double-strand breaks in control or MiDAC-deficient cells
ChIP-Seq mapping of H2AK5ac, H2AK9ac, DNTTIP1, MIDEAS, and LIG4 at AsiSI-induced DNA double-strand breaks in control or MiDAC-deficient cells
PRJNA987699 | ENA
GenomicsChIP-Seq mapping of H2AK5ac, H2AK9ac, DNTTIP1, MIDEAS, and LIG4 at AsiSI-induced DNA double-strand breaks in control or MiDAC-deficient cells
To test whether MiDAC-promoted H2AK5/K9 deacetylation is implicated in DSB response, we took advantage of an improved DSB-induced via AsiSI (AiDIvA) system, in which the endonuclease restriction enzyme AsiSI is fused to the estrogen receptor (ER) hormone-binding domain and its nuclear expression in ...
ORGANISM(S): Homo sapiens 
2024-02-16 | GSE235845 | GEO
TranscriptomicsDe novo mutations in the MiDAC HDAC complex cause a neurodevelopmental 2 syndrome resulting from increased deacetylase activity [RNA-seq]
MIDEAS is a scaffold protein that, together with DNTTIP1, mediates assembly of the MiDAC histone deacetylase complex. Mice lacking MiDAC die before birth suggesting a key developmental function. Here, we report two unrelated individuals, with a multisystem disorder characterized by delayed speech de...
ORGANISM(S): Homo sapiens Mus musculus 
2025-10-13 | GSE297959 | GEO
OtherDe novo mutations in the MiDAC HDAC complex cause a neurodevelopmental 2 syndrome resulting from increased deacetylase activity [qPRO-seq]
MIDEAS is a scaffold protein that, together with DNTTIP1, mediates assembly of the MiDAC histone deacetylase complex. Mice lacking MiDAC die before birth suggesting a key developmental function. Here, we report two unrelated individuals, with a multisystem disorder characterised by delayed speech de...
ORGANISM(S): Homo sapiens 
2025-10-13 | GSE297958 | GEO
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