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ProteomicsPolyQ-expanded ataxin-1 formed insoluble protein inclusions perturbing translation in a spinocerebellar ataxia type-1 model
Spinocerebellar ataxia type-1 is caused by an abnormally expanded polyglutamine (polyQ) tract in ataxin-1 protein. These expansions are responsible for protein misfolding and self-assembly into intranuclear inclusion bodies (IIBs) that are linked to neuronal death. Here, we describe a nuclear protei...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD012709 | Pride
Ataxin-1 Sleeping beauty transposon Protein network Polyglutamine Afm Ribosome Nucleolus. Spinocerebellar ataxia type-1 Rna-seq 
ProteomicsSP3 protocol for proteomic plant sample preparation prior LC-MS/MS
Quantitative protein extraction from biological samples, as well as contaminants removal before LC-MS/MS, is fundamental for the successful bottom-up proteomic analysis. Four sample preparation methods, including the filter-aided sample preparation (FASP), two single-pot solid-phase-enhanced sample p...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-02-26 | PXD022688 | Pride
Protein cleanup Arabidopsis thaliana Bottom-up Mass spectrometry Sds removal Sp3 Fasp Carboxylated magnetic beads 
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