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ProteomicsProteomic Characterization of Human Milk Fat Globule Membrane Proteins during a 12 Month Lactation Period
The milk fat globule membrane (MFGM) contains proteins which have been implicated in a variety of health benefits. Milk fat globule membrane proteins were isolated from human milk during a 12 month lactation period and subjected to in solution digestion and liquid chromatography tandem mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-24 | MSV000089722 | MassIVE
TranscriptomicsGene Expression in the Human Mammary Epithelium during Lactation: the Milk Fat Globule Transcriptome through 4 Days
The 4 day gene expression profile in the lactating mammary gland was demonstrated using the Human Ref-8 BeadChip array (Illumina, Inc). Of the 22,184 gene transcripts on the array, 14,070 genes were consistently expressed and represented the milk fat globule transcriptome. Milk protein genes were am...
ORGANISM(S): Homo sapiens 
2011-06-30 | E-GEOD-15208 | biostudies-arrayexpress
TranscriptomicsRole of milk fat globule membrane (MFGM) in modulating gene expression in humans
The aim of this study was to investigate if milk fat globule membrane (MFGM) enclosing the dairy fat influence peripheral blood mononuclear cells (PBMC) gene expression. This study was a 8-week single-blind, randomized, controlled isocaloric trial with two parallel groups including overweight (mean ...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-60148 | biostudies-arrayexpress
TranscriptomicsGene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice
Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice Affymetrix GeneChip® Mouse Genome 430 array was used to study the gene expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-73229 | biostudies-arrayexpress
ProteomicsTranscriptional repression of MFG-E8 causes disturbance in the homeostasis of Cell cycle through DOCK/ZP4/STAT signaling in mammary epithelial cells
The mammary gland is a unique apocrine gland made up of a branching network of ducts that end in alveoli. It is an ideal system to study the molecular mechanisms associated with cell proliferation, differentiation, and oncogenesis. MFG-E8, also known as Lactadherin, is a vital glycoprotein related t...
ORGANISM(S): Bos taurus (Bovine) 
2021-09-09 | PXD022445 | Pride
Milk fat globule epithelial growth factor-8 Quantitative proteomics Cytoscape Cell proliferation Kegg 
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsSeminal plasma and transforming growth factor-β regulate gene expression in human Ect1 ectocervical epithelial cells
In this study we examined the influence of seminal plasma on gene expression in human Ect1 ectocervical epithelial cells, and the extent to which recombinant TGFβ3 elicits comparable changes. Ect1 cells were incubated with recombinant human TGFβ3 (5 ng/ml), 10% pooled human seminal plasma (v/v), or ...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35830 | biostudies-arrayexpress
Transcriptomics24 hrs of AGS cells exposed to H. pylori
H. pylori Outer membrane phospholipase A (OMPLA) has been suggested to play a role in the virulence of this bacterium. The aim of this study was to profile the most significant cellular pathways and biological processes affected in gastric epithelial cells during 24 hours of H. pylori exposure, and ...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-MTAB-846 | biostudies-arrayexpress
TranscriptomicsCag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.
TC1: gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours. Total RNA was used to make single stranded Cy5 labelled probe and compared to Cy3 labelled probe from uninfected AGS cells. Hybridizations of G27 (trial ...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-GEOD-3556 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymphtoxin beta receptor-deficient thymic medullary epithelial cells vs. wild-type and Aire-deficient vs wild-type littermates
We compared gene expression profiles of lymphotoxin alpha- and lymphtoxin beta receptor-deficient thymic medullary epithelial cells with their wild-type littermates, as well as with Aire-deficient and wild-type littermates. This was done in order to determine whether there was overlap in the effects...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8563 | biostudies-arrayexpress
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