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UnknownCalcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain.
Not available
S-EPMC4193543 | biostudies-literature
TranscriptomicsTranscription profiling of human breast cancer tumor samples from Uppsala and Singapore cohorts
Histological grading of breast cancer defines morphological subtypes informative of metastatic potential, although not without considerable inter-observer disagreement and clinical heterogeneity particularly among the moderately differentiated grade II (G2) tumors. We posited that a gene expression ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-4922 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of breast cancer tissue in a large population-based cohort of Swedish patients
Tissue material was collected from all breast cancer patients receiving surgery at Karolinska Hospital from 1994-1996. Material was frozen immediatley on dry ice or in liquid nitrogen and stored in -70°C freezers. This series contains expression data for n=159 tumors from which RNA could be collect...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-1456 | biostudies-arrayexpress
TranscriptomicsNsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus
S. aureus possesses 16 two-component systems (TCS), two of which (GraRS & NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, conserved within the firmicutes. NsaRS has recently been documented as being important for nisin-resistance in S. aureus. In this study we present a d...
ORGANISM(S): Staphylococcus aureus 
2011-05-16 | E-GEOD-27061 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 30 ovarian cancer cell lines reveals amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer
DNA from 30 cultured ovarian cancer cell lines was extracted with Promega kits and hybridize to arrays. Arrays comprised of 1860 BACs selected to include genes known to be involved in cancer pathogenesis and 400 BACs selected to tile across 13 Mbp at 3q26, 15 Mbp at 8q24, and 30 Mbp at 20q centered ...
ORGANISM(S): Homo sapiens 
2007-06-04 | E-TABM-246 | biostudies-arrayexpress
ProteomicsOptimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture
Three-dimensional (3D) organoid models have been instrumental in understanding molecular mechanisms responsible for many cellular processes and diseases. However, established organic biomaterial scaffolds used for 3D hydrogel cultures, such as Matrigel, are biochemically complex and display signific...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD045193 | Pride
Mammary epithelial cell 3d Laminin Organoid 
UnknownCircular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.
Not available
S-EPMC12281749 | biostudies-literature
TranscriptomicsAn Epigenetic Signature in Peripheral Blood Associated with Neurodegenerative Tauopathy and the Risk-Associated Haplotype on 17q21.31
Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are two neurodegenerative diseases linked, at the pathologic and genetic level, to the macrutubule associated protein tau. We identified and replicated a dose-dependent effect of the risk-associated H1 haplotype on methylation le...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
GenomicsMutational evolution in a lobular breast tumour profiled at single nucleotide resolution
We have used next generation sequencing to sequence genomes (>43-fold coverage) and transcriptomes of an oestrogen-receptor-alpha-positive metastatic lobular breast cancer at depth. We found 32 somatic non-synonymous coding mutations present in the metastasis, and measured the frequency of these som...
EGAS00000000054 | EGA
GenomicsWTCCC2 Visceral Leishmaniasis (VL) samples
A WTCCC2 project genome-wide association study for visceral leishmaniasis (VL) in individuals from India, Brazil and Sudan, genotyped on the custom Illumina 670k array. The WTCCC2 analysis of the Brazilian and Indian samples is described in Fakiola et al. [Nat Genet. 2013 Feb;45(2):208-13]. It shoul...
EGAS00001000773 | EGA
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