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UnknownSmoking, alcohol, and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people.
In China, the incidence of pancreatic cancer (PC) has increased in recent decades. However, little is known about the relevance to PC risk of lifestyle and behavioral factors such as smoking, alcohol drinking, and diet. The China Kadoorie Biobank prospective study recruited 512,891 adults (210,222 m...
S-EPMC5773963 | biostudies-literature
UnknownDiabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million Chinese adults and a meta-analysis of 22 cohort studies.
Diabetes is associated with an increased risk of pancreatic cancer (PC) in Western populations. Uncertainty remains, however, about the relevance of plasma glucose for PC among people without diabetes and about the associations of diabetes and high blood glucose with PC in China where the increase i...
S-EPMC5396360 | biostudies-literature
UnknownEvaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.

Aims/hypothesis

Genome-wide association studies (GWAS) have discovered many risk variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 diabetes predisposition are often based on highly selected case-control samples, and reliable estimates of populat...
S-EPMC4901105 | biostudies-literature
UnknownComparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults.
Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of prote...
S-EPMC11845630 | biostudies-literature
UnknownPhenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

Background

China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population.

Methods

Based on summary statistics of existing genome-wide association studies in East Asian ancestry (EAS) and European ancestr...
S-EPMC12907099 | biostudies-literature
UnknownAssociations of 2923 Olink proteins with demographic, lifestyle, environmental and health characteristics in middle-aged Chinese adults.
Not available
S-EPMC12660334 | biostudies-literature
UnknownTobacco smoking and risks of more than 470 diseases in China: a prospective cohort study.

Background

Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues to increase in men. Large nationwide prospective studies linked to different health records can help to periodically assess disease burden attributed to smoking. We a...
S-EPMC7613927 | biostudies-literature
UnknownHealthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease.

Background

DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with coronary heart disease (CHD), especially in the Asian population.

Res...

S-EPMC10045869 | biostudies-literature
UnknownGenetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults.
In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations of genetically predicted type 2 diabetes with CVD among ∼160,000 participants to assess whether these...
S-EPMC6804628 | biostudies-literature
UnknownCausal association between snoring and stroke: a Mendelian randomization study in a Chinese population.

Background

Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke.

Methods

Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoor...
S-EPMC10832459 | biostudies-literature
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