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ProteomicsSequential elution interactome analysis of Mind bomb 1 and a novel role in dendritic spine outgrowth
Mind bomb 1 (Mib1) is an E3 ubiquitin-ligase that is essential for overall metazoan development, including multiple stages of neuronal development. It is located in puncta throughout neurons, including near post synaptic densities (PSD), and has been shown to participate in several signaling pathway...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001255 | Pride
Proteomics Mass spectrometry Notch signaling Wnt signaling Neuronal morphogenesis Dendritic spines Affinity purification E3 ligase Endocytosis Interactome 
ProteomicsEndothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ whic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-14 | MSV000091279 | MassIVE
ProteomicsMind Bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death
Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by dermal inflammation and epidermal abnormalities. TNF and caspase-8-driven cell death c...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-25 | PXD045850 | Pride
Sharpin Tnf Cpdm Dermatitis Mind bomb 2 
TranscriptomicsRNA from 3 d and 2 d old embryos of mibta52b, mibm132 and mibtfi91, and RNA from 3 d, 2d and 1 d old embryos of mibta52b
The Notch signaling is an evolutionarily conserved signal transduction cascade that plays essential roles in a variety of developmental processes. In this study, we examined the mib mutants for defects in pancreas development using in situ hybridization and GFP expression analysis of pancreas-specif...
ORGANISM(S): Danio rerio 
2010-06-25 | E-GEOD-8522 | biostudies-arrayexpress
UnknownMind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner.
Not available
S-EPMC3124443 | biostudies-literature
UnknownMind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.
Not available
S-EPMC5912950 | biostudies-literature
UnknownMind bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death.
Not available
S-EPMC10753164 | biostudies-literature
TranscriptomicsTranscriptome Analysis of the Zebrafish Mind Bomb Mutant
To identify the genes differentially expressed in the zebrafish mibta52b mutant, genome-wide transcriptome analysis was performed using Serial Analysis of Gene Expression (SAGE). 335 transcripts were identified whose expressions were significantly altered in the mibta52b mutant as compared with the ...
ORGANISM(S): Danio rerio 
2008-10-08 | E-GEOD-13050 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of the Zebrafish Mind Bomb Mutant
To identify the genes differentially expressed in the zebrafish mibta52b mutant, genome-wide transcriptome analysis was performed using Serial Analysis of Gene Expression (SAGE). 335 transcripts were identified whose expressions were significantly altered in the mibta52b mutant as compared with the ...
ORGANISM(S): Danio rerio 
2008-10-08 | GSE13050 | GEO
UnknownSequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.
Not available
S-EPMC4587327 | biostudies-literature
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