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TranscriptomicsSharpin controls differentiation and cytokine production of mesenchymal bone marrow cells
The cytosolic protein Sharpin is as a component of the linear ubiquitin chain assembly complex (LUBAC), which regulates NF-κB signaling in response to specific ligands. Its inactivating mutation in Cpdm (chronic proliferative dermatitis mutation) mice causes multi-organ inflammation, yet this phenot...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-61299 | biostudies-arrayexpress
ProteomicsMind Bomb 2 limits inflammatory dermatitis in Sharpin mutant mice independently of cell death
Skin inflammation is a complex process implicated in various dermatological disorders. The chronic proliferative dermatitis (cpd) phenotype driven by the cpd mutation (cpdm) in the Sharpin gene is characterized by dermal inflammation and epidermal abnormalities. TNF and caspase-8-driven cell death c...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-25 | PXD045850 | Pride
Sharpin Tnf Cpdm Dermatitis Mind bomb 2 
TranscriptomicsSHARPIN regulates collagen architecture and ductal invasion in the developing mouse mammary gland
Primary mammary gland stromal fibroblasts from pubertal SHARPIN-deficient cpdm/cpdm -mice and their littermate controls
ORGANISM(S): Mus musculus 
2016-12-15 | GSE83795 | GEO
TranscriptomicsSharpin controls differentiation and cytokine production of mesenchymal bone marrow cells
The cytosolic protein Sharpin is as a component of the linear ubiquitin chain assembly complex (LUBAC), which regulates NF-κB signaling in response to specific ligands. Its inactivating mutation in Cpdm (chronic proliferative dermatitis mutation) mice causes multi-organ inflammation, yet this phenot...
ORGANISM(S): Mus musculus 
2015-09-07 | GSE61299 | GEO
TranscriptomicsAngiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis
Angiogenesis is a common feature of pathological processes including wound healing, tumor formation, and chronic inflammation. Chronic inflammation can also be associated with dilation or proliferation of lymph vessels. We examined blood vessels and lymphatics and the expression of pro- and anti-ang...
ORGANISM(S): Mus musculus 
2016-05-21 | GSE81683 | GEO
TranscriptomicsSystems analysis identifies an essential role for SHARPIN in macrophage TLR2 responses (Agilent)
Our systems analysis reported here demonstrates that TLR-responses in macrophages are markedly impaired by SHARPIN deficiency, and that SHARPIN controls expression of a subset of TLR2-induced, NF-kB and AP-1 dependent genes that overlaps with those affected by the hypomorphic panr2 mutation in NEMO....
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-29888 | biostudies-arrayexpress
UnknownImmune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.
Not available
S-EPMC8685717 | biostudies-literature
UnknownDistinct role of IL-1β in instigating disease in Sharpincpdm mice.
Not available
S-EPMC5125001 | biostudies-literature
UnknownAngiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.
Not available
S-EPMC5164954 | biostudies-literature
UnknownCutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
Not available
S-EPMC4048763 | biostudies-literature
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