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ProteomicsSignaling network response to alpha-particle targeted therapy with actinium-225 labeled minigastrin analogue 225Ac-PP-F11N
Alpha-particle emitters have recently been explored as valuable therapeutic radionuclides. Yet, toxicity to healthy organs and cancer radioresistance limit the efficacy of targeted alpha-particle therapy (TAT). Identification of the radiation-activated mechanisms, which drive cancer cell survival, p...
ORGANISM(S): Homo sapiens (Human) 
2023-06-02 | PXD039033 | Pride
Human Cancer Proteomics Radioresistance Phosphoproteomics Minigastrin 
UnknownImproved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin 177Lu-PP-F11N.
Not available
S-EPMC8199036 | biostudies-literature
UnknownSignificant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs.
Not available
S-EPMC10907560 | biostudies-literature
UnknownInvestigation of the structure-activity relationship at the N-terminal part of minigastrin analogs.
Not available
S-EPMC10329608 | biostudies-literature
UnknownCholecystokinin-2 Receptor Targeting with Novel C-terminally Stabilized HYNIC-Minigastrin Analogs Radiolabeled with Technetium-99m.
Not available
S-EPMC6469167 | biostudies-literature
UnknownEvaluation of Actinium-225 Labeled Minigastrin Analogue [225Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy.
Not available
S-EPMC7696055 | biostudies-literature
UnknownDevelopment of the First 18F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety.
Not available
S-EPMC10054553 | biostudies-literature
UnknownStabilization Strategies for Linear Minigastrin Analogues: Further Improvements <i>via</i> the Inclusion of Proline into the Peptide Sequence.
Not available
S-EPMC7734625 | biostudies-literature
ProteomicsCancer responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
The vast majority of our knowledge regarding cancer radiobiology and the activation of radio-resistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the cancer response to internal targeted radionuclide therapy (TRT). Our comparative proteomi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036034 | Pride
Human Cancer Proteomics Radioresistance Phosphoproteomics Minigastrin 
UnknownEffects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs.
Not available
S-EPMC9959130 | biostudies-literature
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