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Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT
Systematic identification of minor histocompatibility antigens informs outcomes after allogeneic stem cell transplantation
Systematic identification of minor histocompatibility antigens informs outcomes after allogeneic stem cell transplantation
Minor histocompatibility (H) antigens are the molecular targets of allo-immunity responsible both for the development of anti-tumor effects and for graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, despite their potential clinical use, our ...
ORGANISM(S): Homo sapiens 
Minor histocompatibility (H) antigens are the molecular targets of allo-immunity responsible both for the development of anti-tumor effects and for graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, despite their potential clinical use, our k...
ORGANISM(S): Homo sapiens 
2008-01-01 | GSE10044 | GEO
To predict shared graft versus leukemia minor histocompatibility antigens (mHAs) from the DISCOVeRY-BMT dataset. Via mass spectrometry, we then validated predicted mHAs in cell lines with the corresponding HLA allele and nonzero RNAseq reads corresponding to the source gene of the mHA.
ORGANISM(S): Homo sapiens 
2022-12-06 | GSE212013 | GEO
Cellular immunotherapy has proven to be effective in the treatment of hematological cancers by donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation and more recently by targeted therapy with chimeric antigen or T-cell receptor-engineered T-cells. However, dependent on t...
ORGANISM(S): Homo sapiens 
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