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ProteomicsMinor intron splicing efficiency increases with the development of lethal prostate cancer
Minor intron-containing genes (MIGs) are crucial cell cycle regulators and are essential for cell survival. Thus, we explored whether MIGs play a role in cancer progression and cancer therapy resistance. Here we show that MIG-expression segregates sensitive and resistant prostate cancer cells from e...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD026949 | Pride
Minor spliceosome Lineage plasticity Minor intron genes U6atac Prostate cancer 
TranscriptomicsDevelopmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes
RNA-seq was used to analyze mRNA levels and splicing differences between wild-type (Oregon R) and Smn null mutant larvae. Illumina RNA-seq of Oregon R and Smn mutant age-matched larvae from RNA extracted on day four post egg laying. Conclusions from this study used the publicly available modENCODE ...
ORGANISM(S): Drosophila melanogaster 
2013-08-07 | E-GEOD-49587 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression and intron retention during development in a U12-type splicing-deficient zebrafish mutant [RNA-seq]
To determine the global impact of the clbn mutation on gene expression and efficiency of U2- and U12-type splicing, we analyzed the transcriptome of 108hpf wt and clbn mutant larvae by microarrays and RNA sequencing. RNAseq data was used to characterize intron retention of U2-type and U12-type intro...
ORGANISM(S): Danio rerio 
2014-02-05 | E-GEOD-53758 | biostudies-arrayexpress
GenomicsDefective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
PRJNA575006 | ENA
TranscriptomicsGenome wide mapping of effects of U6atac knockdown on pre-mRNA splicing
This project looks into experimentally identifying all minor introns by knocking down the minor spliceosome's catalytic snRNP, U6atac. Knockdown of U6atac by antisense morpholino followed by examining mRNA splicing by RNA-seq
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-48263 | biostudies-arrayexpress
Genomicsp53 ablation fails to completely rescue microcephaly caused by impaired minor intron splicing
p53 ablation fails to completely rescue microcephaly caused by impaired minor intron splicing
PRJNA707040 | ENA
UnknownMinor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns.
Not available
S-EPMC6717393 | biostudies-literature
ProteomicsChromosomal instability by mutations in the novel minor spliceosome component CENATAC
Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely unknown. Through exome sequencing of patients with constitutional mosaic aneuploidy, we identifie...
ORGANISM(S): Homo sapiens (Human) 
2021-04-07 | PXD024682 | Pride
Minor spliceosome Ccdc84 Aneuploidy Cenatac 
ProteomicsA not so minor role for the minor spliceosome in spermatogenesis
Minor introns have been highly conserved in the genome since their emergence in the last eukaryotic common ancestor and are found in genes related to proliferation, chromatin organization, transcription, and splicing. Here, we show that minor intron-containing genes (MIGs) involved in the gene expre...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-03 | PXD064454 | Pride
Timstof ht Data independent acquisition Spliceosome Spermatogenesis 
Transcriptomicsp53 ablation fails to completely rescue microcephaly caused by impaired minor intron splicing
Mutations in the minor spliceosome components such as RNU4atac, a small nuclear RNA (snRNA), are linked to primary microcephaly. We have reported that in the conditional knockout (cKO) mice for Rnu11, a minor spliceosome snRNA, minor intron splicing defect in minor intron-containing genes (MIGs) reg...
ORGANISM(S): Mus musculus 
2021-09-30 | GSE168366 | GEO
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