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ProteomicsmiR-17-92/106b regulate beta cell mitotic checkpoint and insulin secretion
Adult beta cells in the pancreas are the sole source of insulin in our body. Beta cell loss or increased demand for insulin, impose metabolic challenges because adult beta cells are generally quiescent and infrequently re-enter the cell division cycle. miR-17-92/106b is a family of proto-oncogene mi...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-17 | PXD012610 | Pride
Mouse Lc-msms Mir-17-92/106b 
GenomicsNext Generation Sequencing of langerhans islets of miR-17-92/106b KO vs control
Next Generation Sequencing of langerhans islets of miR-17-92/106b KO vs control
PRJNA522253 | ENA
TranscriptomicsEffect of miR-106b~25 in mouse spermatogenesis and male fertility
We investigated the miRNA cluster miR-106b~25 as potential candidate causing male infertility. We analized single and double KO mice. Single KO show derregulation of multiple molecular pathways and disrupted early spermatogenesys, but retain fertility. Double KO show severely disrupted testicular hi...
ORGANISM(S): Mus musculus 
2020-11-06 | E-MTAB-8964 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing of langerhans islets of miR-17-92/106b KO vs control
NGS was used in order to discover novel downstream targets of the miR-17-92/106b clusters.
ORGANISM(S): Mus musculus 
2019-04-24 | GSE126516 | GEO
UnknownmiR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma.
Not available
S-EPMC4033436 | biostudies-literature
TranscriptomicsEffect of miR17-92 and miR-106b-25 loss in primary calvarial cells
Gene expression profiling of primary calvarial cells with miR-17-92:miR-106b-25 conditional deletion
ORGANISM(S): Mus musculus 
2019-07-04 | GSE114495 | GEO
TranscriptomicsFollicular B (FoB) cells purified from miR-17-92 tKO mice
We have generated a miR-17~92 fl/fl allele whose expression can be turned off conditionally by Cre recombinase in the miR-106a-363-/-;miR-106b-25-/- background. The mice were crossed to CD19-Cre mice to turn off the expression of miR-17~92 specifically in B cells.
ORGANISM(S): Mus musculus 
2014-04-01 | GSE56376 | GEO
TranscriptomicsFollicular B (FoB) cells purified from miR-17-92 tKO mice, stimulated with LPS/IL-4, 13.5hr
We have generated a miR-17~92 fl/fl allele whose expression can be turned off conditionally by Cre recombinase in the miR-106a-363-/-;miR-106b-25-/- background. The mice were crossed to CD19-Cre mice to turn off the expression of miR-17~92 specifically in B cells and stimulated LPS/IL-4 for 13.5hr.
ORGANISM(S): Mus musculus 
2014-04-01 | GSE56378 | GEO
TranscriptomicsRibosome Profiling analysis of Follicular B (FoB) cells purified from WT, miR-17~92 transgenic and miR-17-92 tKO mice
We have generated a miR-17~92 transgene and fl/fl allele whose expression can be turned on and off conditionally by Cre recombinase. The mice were crossed to CD19-Cre mice to turn on and off the expression of miR-17~92 specifically in B cells and stimulated LPS/IL-4 for 25.5hr. tKO mice were generat...
ORGANISM(S): Mus musculus 
2017-03-08 | GSE83684 | GEO
TranscriptomicsFollicular B (FoB) cells purified from miR-17-92 tKO mice
We have generated a miR-17~92 fl/fl allele whose expression can be turned off conditionally by Cre recombinase in the miR-106a-363-/-;miR-106b-25-/- background. The mice were crossed to CD19-Cre mice to turn off the expression of miR-17~92 specifically in B cells. Follicular B(FoB) cells were purifi...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-56376 | biostudies-arrayexpress
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