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TranscriptomicsGene expression profiling of immortalized normal fibroblasts from a breast cancer patient after transient transfection with miR-9 or control.
To clarify the molecular alterations triggered by miR-9 to induce the conversion of breast normal fibroblasts to a CAF-phenotype, gene expression profile of normal fibroblasts transiently transfected with miR-9 or control was performed. We performed a gene expression profiling of immortalized normal...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-GEOD-76996 | biostudies-arrayexpress
TranscriptomicsmicroRNA-132/212 deficiency enhances Ab production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
The abnormal regulation of amyloid-b (Ab) metabolism (e.g., production, cleavage, clearance) plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to participate in AD progression are the small regulatory non-coding microRNAs (miRs). In particular, the miR-132/212 clu...
ORGANISM(S): Mus musculus 
2016-07-17 | E-GEOD-84481 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line
mRNA expression profile modified by stable transfection of microRNA mir-517a (MIR517A) in a human hepatocellular carcinoma cell line Huh-7 Keywords: Hepatocellular carcinoma, Expression array, microRNA microRNA mir-517a (MIR517A) was transfected to Huh-7 cells using GFP-expressing lentiviral vector...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20679 | biostudies-arrayexpress
TranscriptomicsDeregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients
Presence of BM-infiltrating neuroblastoma (NB) cells occurs in about 50% of patients affected by this peculiar pediatric cancer. Children aged more than 18 months at diagnosis with metastatic NB are high-risk patients with 25-30% overall survival at 5 years, despite multimodal aggressive therapy. Li...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-65153 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for acute T-cell leukemia/lymphoma (ATL)
SNP array analysis was performed using 168 ATL specimens. To obtain genotypes and intensities for each SNP, Affymetrix 250K SNP arrays were performed for 168 ATL samples.
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33602 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of transcript level regulation of metabolism during human adipocyte differentiation [miR]
Here, we have focused on studying the link between metabolic changes driven by the differentiation into mature adipocytes of a human preadipocyte cell line (SGBS) and their regulation, through a combined experimental and computational approach. By collecting data on gene expression, PPARg, CEBPa, LX...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-41576 | biostudies-arrayexpress
TranscriptomicsIntegrative genomic approach reveals expression of intronic miR-335, miR-342, and miR-561 in multiple myeloma
The role of microRNAs (miRNAs) in multiple myeloma (MM) has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those mapping within transcription units, based on evidence that intronic miRNAs are frequently coexpressed with their host genes. To thi...
ORGANISM(S): Homo sapiens 
2008-11-10 | E-GEOD-11522 | biostudies-arrayexpress
TranscriptomicsIdentification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients
In the majority of colorectal cancers (CRC) under clinical suspicion for a hereditary cause, the disease-causing genetic factors are still to be discovered. In order to identify such genetic factors we stringently selected a discovery cohort of 41 CRC index patients with microsatellite-stable tumors...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-13429 | biostudies-arrayexpress
TranscriptomicsSmall tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C
Small, non-coding RNAs control gene expression post-transcriptionally and play important roles in virus-host interactions. Within the liver, the microRNA (miRNA) miR-122 is essential for replication of hepatitis C virus (HCV), while repression of miR-148a by hepatitis B virus (HBV) may enhance tumor...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-57381 | biostudies-arrayexpress
TranscriptomicsIdentification of p130Cas/ErbB2 dependent invasive signatures in transformed mammary epithelial cells.
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is over-expressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Ca...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43907 | biostudies-arrayexpress
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