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ProteomicsConvergent Activation of the Integrated Stress Response and ER–Mitochondria Uncoupling in VAPB-Associated ALS
Human iPSC-derived motor neurons with either VAPB WT or VAPB P56S expressed under the control of a doxycycline inducible promoter were grown out to day 35 of motor neuron differentiation. A co-immunoprecipitation was then performed using the VAPB protein as bait to determine the interactome of VAPB ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD065524 | Pride
Als type viii Mitochondria Vapb Isr Isrib Er-mam Als Neurodegeneration 
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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