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ProteomicsMultiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve
Neural regeneration and neuroprotection represent promising therapeutic approaches for neurodegenerative disorders like Alzheimer's disease (AD) or glaucoma. However, the molecular mechanisms that lead to neuroprotection are not clearly understood. One of the promising candidates to revive physiolog...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-12 | PXD046873 | Pride
Neuroserpin Frontal cortex Brain Tmt proteomics Cerebellum Optic nerve Visual cortex Retina 
ProteomicsH3K9me3 epigenetic derepression reverses Alzheimer’s-like pathology and improves cognition via immunomodulation and Vgf network activation
Alzheimer's disease (AD) is associated with excessive epigenome histone 3 lysine 9 trimethylation (H3K9me3), repressing genes involved in synaptic plasticity and memory. In this study, we explored the therapeutic potential of ETP69, an inhibitor of the H3K9me3 methyltransferase SUV39H1, in both old ...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD041527 | Pride
H3k9me3 Alzheimer's disease Vgf Proteomics 
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