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TranscriptomicsThe effect of Neuroserpin expression upon HeLa cell gene expression
HeLa cells were stably transfected using the Tet-OnM-BM-. Advanced Cell Line system with Wildtype, G392E and Delta Neuroserpin with neuroserpin expression induced with doxycycline. Gene expression was examined in the absence or presence of 2 ug/ml doxycycline. Four cell lines were analysed: Untran...
ORGANISM(S): Homo sapiens 
2013-04-20 | E-GEOD-46230 | biostudies-arrayexpress
ProteomicsNeuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome
Neuroserpin is a serine protease inhibitor that regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin is strongly expressed during nervous system development as well as during adulthood, when it is predominantly found in regions eliciting synaptic plast...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-23 | PXD022371 | Pride
Mus musculus Development Neuroserpin Bottom-up proteomics Cerebral cortex 
ProteomicsMultiple plex quantitative proteomic analysis of neuroserpin-deficient and control mice, for the murine brain, retain and optic nerve
Neural regeneration and neuroprotection represent promising therapeutic approaches for neurodegenerative disorders like Alzheimer's disease (AD) or glaucoma. However, the molecular mechanisms that lead to neuroprotection are not clearly understood. One of the promising candidates to revive physiolog...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-12 | PXD046873 | Pride
Neuroserpin Frontal cortex Brain Tmt proteomics Cerebellum Optic nerve Visual cortex Retina 
TranscriptomicsThe effect of Neuroserpin expression upon HeLa cell gene expression
HeLa cells were stably transfected using the Tet-On® Advanced Cell Line system with Wildtype, G392E and Delta Neuroserpin with neuroserpin expression induced with doxycycline. Gene expression was examined in the absence or presence of 2 ug/ml doxycycline.
ORGANISM(S): Homo sapiens 
2013-04-20 | GSE46230 | GEO
UnknownNeuroserpin: structure, function, physiology and pathology.
Not available
S-EPMC8558161 | biostudies-literature
UnknownThe tempered polymerization of human neuroserpin.
Not available
S-EPMC3295756 | biostudies-literature
UnknownHuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein.
Not available
S-EPMC115279 | biostudies-literature
UnknownNeuroserpin: A Potential Neuroprotective Agent in Mild Neonatal Hypoxic-Ischaemic Encephalopathy.
Not available
S-EPMC12691123 | biostudies-literature
UnknownThe endoplasmic reticulum (ER)-associated degradation system regulates aggregation and degradation of mutant neuroserpin.
Not available
S-EPMC3121498 | biostudies-literature
UnknownInteractions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum.
Not available
S-EPMC4949553 | biostudies-literature
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