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UnknownEvidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.
Not available
S-EPMC3236649 | biostudies-literature
ProteomicsmTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter...
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD006461 | Pride
Mtorc2 Xct 
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
Genomicsena-DATASET-BGI-31-12-2014-03:23:33:590-567 - samples
Gastric Cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencin...
EGAD00001001118 | EGA
GenomicsWGS and WES of 78 pairs Chinese gastric cancer
Gastric Cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencin...
EGAS00001001056 | EGA
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