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GenomicsSignatures of mismatch repair deficiency in cancer genomes
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient tumors and observed that mutation rates were drastically increased relative to MMR-proficient end...
EGAS00001000182 | EGA
TranscriptomicsTranscription profiling of three human colorectal adenocarcinoma cells lines two which are mismatch repair deficient to characterize the post-transcriptional profile
characterize the post-transcriptional profile of mismatch repair-deficient colon cancer
ORGANISM(S): Homo sapiens 
2008-07-15 | E-MEXP-1696 | biostudies-arrayexpress
GenomicsInterrelationships between replication infidelity and genome composition
An enduring issue in evolutionary and cancer biology is how replication infidelity influences genome composition and vice versa. Here we examine this issue by sequencing the genomes of diploid budding yeast strains that are either mismatch repair (MMR) proficient or deficient and encode wild type or...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-25 | E-GEOD-56939 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of miRNA levels in colon cancer
Analysis of miRNA levels found in tissue obtained from proficient mismatch repair (pMMR) TNM stage 2|3|4 colon tumor, deficient MMR (dMMR) colon tumor, and normal colon. miRNA levels obtained from macrodissected colon tumors with > 70% H&E staining were compared with normal colon tissue. Additional ...
ORGANISM(S): Homo sapiens 
2010-03-18 | E-GEOD-18392 | biostudies-arrayexpress
ProteomicsHuman DNA Mismatch Repair pathway LC-MSMS
The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base-base and insertion-deletion mismatches generated during DNA replication. To systematically investigate the mismatch repair pathway, we conducted a proteomic analysis and identified MMR-associate...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079578 | MassIVE
ProteomicsMCM9 is Required for Mammalian DNA Mismatch Repair
DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects innate DNA polymerase infidelities during replication to maintain genomic integrity. Defects in a subset of MMR genes are associated with hereditary non-polyposis colon cancer and some other sporadic cancers, highlighting...
ORGANISM(S): Homo sapiens (Human) 
2015-08-19 | PXD000212 | Pride
Mcm9 human dna replication helicase mmr mismatch repair 
GenomicsGENOMIC INSTABILITY IN MISMATCH REPAIR DEFICIENT COLORECTAL CANCER
Here we performed whole exome sequencing on a series of 47 mismatch repair (MMR) deficient colorectal cancers (CRC) in order to identified key events in tumoral initiation and progression
EGAS00001002477 | EGA
ProteomicsNuclear Phosphatidylinositol 3-Phosphate Produced by Beclin-1/Vps34 Directly Orchestrates DNA Mismatch Repair
DNA mismatch repair (MMR) is essential for maintaining genome integrity, yet its regulation by non-protein biomolecules remains poorly understood. Here, we uncover nuclear phosphatidylinositol 3-phosphate (PI3P) as a previously unrecognized lipid mediator of MMR. PI3P, canonically produced by the Be...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066473 | Pride
Autophagy Ip-ms Dna mismatch repair Genome stability 
Genomicsena-DATASET-VIB-29-07-2013-12:55:51:690-38 - samples
DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient endometrial tumors.
EGAD00001000641 | EGA
GenomicsTranscriptomic evaluation of mismatch repair defects
Transcriptomic evaluation of mismatch repair defects
PRJNA489879 | ENA
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