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TranscriptomicsTranscriptome analysis of pancreatic progenitors differentiated from H9 human embryonic stem cells and induced pluripotent stem cells derived from a Mitchell-Riley Syndrome patient
Skin biopsies were obtained from a patient with Mitchell-Riley syndrome caused by a homozygous frame-shift mutation (c.1129C>T) in the RFX6 gene that leads to a premature stop codon (p.Arg377X). The patient suffered severe pancreatic agenesis, in common with other Mitchell-Riley syndrome patients. F...
ORGANISM(S): Homo sapiens 
2020-03-30 | E-MTAB-6626 | biostudies-arrayexpress
ProteomicsSILAC analysis of ptp-3 knockout in C. elegans
A ptp-3 mutant and wildtype C. elegans were SILAC labeled and subjected to whole proteome analysis and phosphotyrosine enrichment.
ORGANISM(S): Caenorhabditis elegans 
2016-12-14 | PXD003233 | Pride
Phosoproteomics C. elegans Silac 
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
TranscriptomicsExpression data from Xenopus anterior gut RFX6 knockdown
Recently a new neonatal diabetes syndrome, Mitchell-Riley syndrome, was discovered. To identify the genetic cause of the syndrome homozygosity mapping was used, several chromosomal regions were linked to Mitchell-Riley syndrome. In situ hybridization of genes from one such region using model organ...
ORGANISM(S): Xenopus laevis 
2011-01-24 | E-GEOD-23642 | biostudies-arrayexpress
UnknownLamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress.
Not available
S-EPMC4725441 | biostudies-literature
TranscriptomicsTranscriptome analysis of pancreatic endoderm differentiated from induced pluripotent stem cells derived from a patient with Mitchell-Riley Syndrome and her unaffected father
Skin biopsies were obtained from a patient with Mitchell-Riley syndrome and her unaffected father. The patient suffered neonatal diabetes, anaemia, intrauterine growth restriction, pancreatic hypoplasia and duodenal atresia, in common with other Mitchell-Riley syndrome patients. The disease was foun...
ORGANISM(S): Homo sapiens 
2020-10-23 | E-MTAB-9243 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of pre- and post-mouse H. pylori strains SS1 and SS2000
This experiment set contains the raw data for 8 arrays that were used in the genomic typing of the pre- and post-mouse H. pylori strains SS1 and SS2000. 10700 is the pre-mouse clinical isolate of SS1 and PMSS2000 is the pre-mouse clinical isolate of SS2000. gDNA from these strains were labeled and h...
ORGANISM(S): Helicobacter pylori 
2005-11-03 | E-SMDB-1734 | biostudies-arrayexpress
ProteomicsUbiquitin mediated intracellular trafficking is required for Jam-C function
Endothelial cells form a barrier between the components present in the blood and the underlying tissue. Essential to formation of this barrier are junctional complexes present between cells. These complexes are dynamic, tightly regulated and remodel during key physiological processes such as inflamm...
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD013003 | Pride
Proteomics Intracellular trafficking Endothelial cells Jam-c Ubiquitin Lc-ms/ms 
TranscriptomicsEndothelial C/EBPβ/AEP Pathway Drives Vascular Deterioration and Systemic Aging
Age-related microvascular dysfunction disrupts nutrient homeostasis and waste clearance, leading to organ failure. However, a critical gap remains in our understanding of the specific molecular drivers of vascular deterioration and how they orchestrate organism-wide aging. Here, we identify progress...
ORGANISM(S): Mus musculus 
2026-05-30 | E-MTAB-17006 | biostudies-arrayexpress
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
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