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ProteomicsUbiquitin mediated intracellular trafficking is required for Jam-C function
Endothelial cells form a barrier between the components present in the blood and the underlying tissue. Essential to formation of this barrier are junctional complexes present between cells. These complexes are dynamic, tightly regulated and remodel during key physiological processes such as inflamm...
ORGANISM(S): Homo sapiens (Human) 
2019-11-06 | PXD013003 | Pride
Proteomics Intracellular trafficking Endothelial cells Jam-c Ubiquitin Lc-ms/ms 
GenomicsGenome-wide analysis of the JAM-C over-expressed trophoblasts
Genome-wide analysis of the JAM-C over-expressed trophoblasts
PRJNA657204 | ENA
GenomicsExpression Data from JAM-C or TAZ overexpressing ARPE-19 cells
Expression Data from JAM-C or TAZ overexpressing ARPE-19 cells
PRJNA1057047 | ENA
TranscriptomicsGenome-wide analysis of the JAM-C over-expressed trophoblasts
During pregnancy, trophoblasts in the placenta are important in the success of pregnancy. We identify an adhesion molucule, JAM-C, which expresses on membrane of column cytotrophoblasts and regulates the differentiation and migration of trophoblasts. Primary cytotrophoblasts isolated from 1st trimes...
ORGANISM(S): Homo sapiens 
2020-10-31 | GSE156258 | GEO
UnknownMurine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.
Not available
S-EPMC4986712 | biostudies-literature
UnknownDual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion.
Not available
S-EPMC1237098 | biostudies-literature
TranscriptomicsExpression Data from JAM-C or TAZ overexpressing ARPE-19 cells
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a hallmark of PVR, which remains an unresolved clinical challenge leading to vision loss. Here, we identified disregulation of junctional adhesion molecule C (JAM-C) and transcriptional co-activator with PDZ-binding...
ORGANISM(S): Homo sapiens 
2025-12-30 | GSE251997 | GEO
UnknownJAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
Not available
S-EPMC1988941 | biostudies-literature
UnknownJAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway.
Not available
S-EPMC12869230 | biostudies-literature
UnknownGenetic deletion of JAM-C reveals a role in myeloid progenitor generation.
Not available
S-EPMC2651011 | biostudies-literature
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