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Genomicshuman gut metagenome
Butyrate 2012 Metagenome
PRJNA183959 | ENA
UnknownRestoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Not available
S-EPMC5755977 | biostudies-literature
MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-12 | PXD043122 | Pride
Protease N-terminomics Legumain Faims 
ProteomicsFunctional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease
Dysregulated proteolysis plays a pivotal role in the pathophysiology of inflammatory bowel disease. Nonetheless, the identity of overactive proteases released by human colonic mucosa remains unknown. Herein, we employed a serine protease-targeted activity-based probe (ABP) coupled with mass spectral...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD009450 | Pride
Inflammation Functional proteomics Activity-based probe Serine protease Inflammatory bowel disease 
TranscriptomicsEndothelial C/EBPβ/AEP Pathway Drives Vascular Deterioration and Systemic Aging
Age-related microvascular dysfunction disrupts nutrient homeostasis and waste clearance, leading to organ failure. However, a critical gap remains in our understanding of the specific molecular drivers of vascular deterioration and how they orchestrate organism-wide aging. Here, we identify progress...
ORGANISM(S): Mus musculus 
2026-05-30 | E-MTAB-17006 | biostudies-arrayexpress
UnknownRisk, Protective, and Associated Factors of Anxiety and Depressive Symptoms and Campus Health Services Utilization Among Black Men on a College Campus.
Not available
S-EPMC8423855 | biostudies-literature
GenomicsInsights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between activated versus repressed genes remain incompletely understood. In this study, we p...
ORGANISM(S): Mus musculus 
2009-11-25 | E-GEOD-16594 | biostudies-arrayexpress
UnknownKi67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Not available
S-EPMC5455353 | biostudies-literature
UnknownProspective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.
Not available
S-EPMC8462523 | biostudies-literature
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