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Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
CRISPRi screening identifies RHOA as a novel MERCS regulator
Organelles form contacts between each other allowing for transfer of molecules and signals. Mitochondria-ER Contact sites (MERCS) are lengths of the Mitochondria and ER membrane which come together but do not fuse. They have been implicated in many diseases, including neurodegenerative, metabolic, a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042710 | Pride
Genomics
RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether
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