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TranscriptomicsGene Expression Profiling for Plk2 -/- mammary gland
Identify gene expression changes in the absence of Plk2 Disruptions in polarity and mitotic spindle orientation contribute to the progression and evolution of tumorigenesis. However, little is known about the molecular mechanisms regulating these processes in vivo. Here we demonstrate that Polo-like...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-50003 | biostudies-arrayexpress
ProteomicsCentrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX) in regulating MS orientation in addition to its well-established role in ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-04 | PXD009747 | Pride
Mitotic spindle orientation Alix Microtubule G-tubulin Map1s 
TranscriptomicsPcs1 and Mde4 are inner centromere proteins required to prevent merotelic kinetochore orientation
Chromosome segregation depends on proper attachment of sister kinetochores to microtubules. Merotelic kinetochore orientation is an error which occurs when a single kinetochore is attached to microtubules emanating form opposite poles. Mechanisms preventing or correcting the merotelic attachment mus...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-10 | E-GEOD-5257 | biostudies-arrayexpress
GenomicsCanonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs
Canonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs
PRJNA1260493 | ENA
ProteomicsFAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning
The concerted action of many protein kinases helps orchestrate the error-free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin-dependent kinases, are well-established. However, these and other known mitotic kinases alone canno...
ORGANISM(S): Homo sapiens (Human) 
2019-07-15 | PXD013808 | Pride
Protein kinase ck1α Mitotic spindle Fam83d 
TranscriptomicsCanonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs
Mitotic spindle orientation is crucial for cell fate determination and tissue organization. Although the intracellular machinery governing spindle orientation is well characterized, whether and how secreted factors, such as morphogens, regulate this process remains poorly understood. This study inve...
ORGANISM(S): Homo sapiens 
2025-06-25 | GSE296672 | GEO
ModelsCaydasi2012 - Regulation of Tem1 by the GAP complex in Spindle Position Checkpoint - Ubiquitous inactive model
Regulation of Tem1 by the GAP complex in Spindle Position Checkpoint - Ubiquitous inactive This model is described in the article: A dynamical model of the spindle position checkpoint. Caydasi AK, Lohel M, Grünert G, Dittrich P, Pereira G, Ibrahim B. Mol. Syst. Biol. 2012; 8: ...
2024-09-02 | BIOMD0000000702 | BioModels
ModelsCaydasi2012 - Inhibition of Tem1 by the GAP complex in Spindle Position Checkpoint
This model is from the article: A dynamical model of the spindle position checkpoint Ayse Koca Caydasi, Maiko Lohel, Gerd Grünert, Peter Dittrich, Gislene Pereira, Bashar Ibrahim Molecular Systems Biology 2012; 582 doi: 10.1038/msb.2012.15 ...
2024-09-02 | BIOMD0000000701 | BioModels
ModelsCaydasi2012 - Regulation of Tem1 by the GAP complex in spindle position cell cycle checkpoint - Ubiquitous association model
Caydasi2012 - Regulation of Tem1 by the GAP complex in spindle position cell cycle checkpoint - Ubiquitous association model This model is described in the article: A dynamical model of the spindle position checkpoint. Caydasi AK, Lohel M, Grünert G, Dittrich P, Pereira G, Ibrah...
2024-09-02 | BIOMD0000000699 | BioModels
ProteomicsMeru co-ordinates spindle orientation with cell polarity and cell cycle progression
Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division. Spindle tethering factors such as Drosophila Mud (NuMA in mammals) are recruited to the cell cortex and capture astral microtubules, pulling...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-03-12 | PXD060813 | Pride
Polarity Meru Spindle 
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