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ProteomicsCentrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics
The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX) in regulating MS orientation in addition to its well-established role in ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-04 | PXD009747 | Pride
Mitotic spindle orientation Alix Microtubule G-tubulin Map1s 
ProteomicsCARM1 mediated methylation controls interactions of ALIX with key partners important for cytokinesis
CARM1 is an arginine methyltransferase with a well-established role in regulating gene expression, but its cytoplasmic functions remain largely uncharacterized. We identified ALIX, a protein acting with the ESCRT-III machinery in numerous membrane remodeling events, as a main cytoplasmic partner and...
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD064697 | Pride
Cytokinesis Peptide pull-down Alix Arginine methylation Methyltransferase 
ProteomicsCARM1-dependent methylation of ALIX in HeLa cells
Hela Cells were treated with a CARM1 inhibitor or with DMSO for 48h. Endogenous ALIX was then immunoprecipitated and sujected to lysarginase digestion. The level of arginine methylation of Arg745 and Arg 757 of ALIX were then analyzed, and compared between the two conditions (CARM1 inhibition versus...
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD064974 | Pride
Carm1 Alix Arginine methylation Hela 
ProteomicsDistinct functions of dimeric and monomeric Alix in regulating F-actin assembly and loading of exosomal cargo
Alix is a ubiquitously expressed scaffold protein that participates in numerous cellular processes, relating to the remodeling/repair of membranes and the actin cytoskeleton. Alix exists in monomeric and dimeric/multimeric configurations, but how dimer formation occurs and what role the dimer has ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031450 | Pride
Exosome Cytoskeleton Disulfide Syntenin Alix Dimerization Actin Homeostasis 
ProteomicsALIX partners in BT549 and in HeLa cells
To characterize ALIX interactome in BT549 cells and in HeLa cells, endogenous ALIX was immunoprecipitated followed by mass spectrometry based analysis
ORGANISM(S): Homo sapiens (Human) 
2026-09-24 | PXD064975 | Pride
ProteomicsIn vitro tyrosine phosphorylation of ALIX
Human ALIX (Uniprot accession no. Q8WUM4) Bro1 and proline-rich domains were recombinantly expressed, purified, and phosphorylated in vitro by tyrosine kinase Src. Phosphorylation products were analyzed by mass spectrometry.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088057 | MassIVE
UnknownAlternative polyadenylation produces two major transcripts of Alix.
Not available
S-EPMC4104816 | biostudies-literature
ProteomicsThe profiling of extracellular vesicle subtypes in Huntington’s disease brains identifies Alix as a novel marker of neuropathology
Background: Huntington’s disease (HD) is an inherited autosomal dominant disorder characterized by progressive degeneration of the striatum and cerebral cortex, caused by a mutation in the huntingtin gene, which includes an aberrant expansion of a CAG repeat. The mutant huntingtin protein accumulate...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD060574 | Pride
Mass spectrometry Extracellular vesicles Huntington’s disease 
UnknownA crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.
Not available
S-EPMC2699623 | biostudies-literature
UnknownNEDD4 family ubiquitin ligase AIP4 interacts with Alix to enable HBV naked capsid egress in an Alix ubiquitination-independent manner.
Not available
S-EPMC11389946 | biostudies-literature
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