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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
TranscriptomicsExpression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls
Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their l...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of MCF7 with CARM1 knocked down
The goal of this study is to identify ERalpha-target genes affected by knocking down of the histone arginine methyltransferase CARM1 in MCF7 breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 knockingdown MCF7 cel...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26259 | biostudies-arrayexpress
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-19 | MSV000090746 | MassIVE
ProteomicsCARM1 substrate identification
The goal of the project was global identification of CARM1 substrates. Arginine methylation landscapes were profiled and compared in wild type and CARM1 knockout cells to determine in vivo substrates of CARM1.
ORGANISM(S): Homo sapiens (Human) 
2017-07-03 | PXD005871 | Pride
Mcf7 Mda-mb-231 Orbitrap fusion lumos Bottom-up Arginine methylation 
GenomicsBAF155 methylation at R1064 creates unique chromatin association patterns
CARM1, a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the functions of CARM1 in tumorigenesis, we knocked out CARM1 from several breast cancer cell lines using Zinc-Finger Nuclease technology, which resulted in drastic phenotypic and ...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-52964 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of CARM1 overexpression in MCF7
The goal of this study is to identify ERalpha-target genes affected by overexpression of the histone arginine methyltransferase CARM1 in breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 overexpressing MCF7 cell ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26454 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HeLa cells follwing siRNA mediated knock down of the arginine methyltransferases CARM1 and/or PRMT1
siRNA mediated knockdown of the arginine methyltransferases CARM1 and/or PRMT1 in HeLa cells
ORGANISM(S): Homo sapiens 
2007-08-30 | E-MEXP-1173 | biostudies-arrayexpress
ProteomicsMouse Muscle Quadricep Methylation CARM1 KO
CARM1 muscle KO mice were generated and quadricep muscle tissue was subjected to high pH strong cation exchange and immunoaffinity purification to enrich methyl peptides.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-05 | PXD028884 | Pride
Arginine Carm1 Prmt4 Immunoaffinity Adma Methylation Mouse Sdma Lcms Muscle 
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD038237 | Pride
Arginine methylation Carm1 Nfib Trim29 Sclc 
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