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GenomicsNFIB: A Governor of Epithelial-Melanocyte Stem Cell Behaviour in a Shared Niche
To identify direct NFIB target genes in HFSCs, we performed chromatin immunoprecipitation and deep sequencing (ChIP-seq) analysis using FACS-isolated HFSCs. Two independent NFIB ChIP-seq experiments were conducted.
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-42900 | biostudies-arrayexpress
TranscriptomicsNFIB is a driver of SCLC initiation, progression and metastasis in mouse and marks metastatic disease in patients
Small Cell Lung Cancer (SCLC) is the most aggressive type of lung cancer with early metastatic dissemination and invariable development of resistant disease for which no effective treatment is available to date. Mouse models of SCLC based on inactivation of Rb1 and Trp53 developed earlier showed fre...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-82005 | biostudies-arrayexpress
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-11-19 | MSV000090746 | MassIVE
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
ProteomicsThe NFIB/CARM1 Partnership is a Therapeutic Target for Small Cell Lung Cancer
This project identified NFI family members as CARM1 substrates. NFIB was previously reported to play a critical role in the development of small cell lung cancer. We provided evidence that the arginine methylation of NFIB is required for its oncogenic function in small cell lung cancer.
ORGANISM(S): Homo sapiens (Human) 
2023-02-07 | PXD038237 | Pride
Arginine methylation Carm1 Nfib Trim29 Sclc 
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
GenomicsIdentifying NFIB target genes in mammalian cells
Identifying NFIB target genes in mammalian cells
PRJNA907825 | ENA
ProteomicsSAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA
Neural stem cell regulation is essential for the formation of the central nervous system and homeostatic neurogenesis in the adult mammalian brain. The RNAseIII Drosha, a key component of the miRNA microprocessor, plays a central role in regulating NSC maintenance partially through a miRNA-independe...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-03 | PXD017677 | Pride
Neural stem cell Drosha 
TranscriptomicsPregnancy-induced gene expression and differentiation of mouse mammary epithelium are co-governed by Nuclear Factor IB (NFIB) and STAT5
Cytokines control the expression of common and cell-specific genes through the transcription factor STAT5. In mammary tissue specifically, expression of approximately 570 genes is induced during pregnancy by prolactin through STAT5, which binds to putative regulatory sequences. We have now asked whe...
ORGANISM(S): Mus musculus 
2012-12-13 | E-GEOD-42878 | biostudies-arrayexpress
GenomicsMolecular basis of NFIB-Mediated Regulation of Oncogenic Transcription
Molecular basis of NFIB-Mediated Regulation of Oncogenic Transcription
PRJNA1303094 | ENA
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