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TranscriptomicsMDA-9/Syntenin regulates differentiation and angiogenesis programs in Head and Neck Squamous Cell Carcinoma
We identified MDA-9/Syntenin (8q12) as a key component of HNSCC differentiation and angiogenesis. Robust reduction in the expression of cyclinD1, CDK4, CTNNB1, STAT3 and PI3K were evident in MDA- 9/Syntenein depleted cells, which was reversed following MDA-9/Syntenin overexpression in immortalized o...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-57760 | biostudies-arrayexpress
TranscriptomicsSyntenin-1 is expressed in uveal melanoma and correlates with metastatic progression
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, being at that time almost always fatal. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-27831 | biostudies-arrayexpress
ProteomicsSyntenin inhibition impairs stroma-tumor communication in Multiple Myeloma and improves Bortezomib treatment efficiency
In multiple myeloma, the objective is to assess the impact of syntenin knockout on the secretory profile of bone marrow stromal cells using the HS-5 model.
ORGANISM(S): Homo sapiens (Human) 
2025-07-26 | PXD064458 | Pride
Lc-msms Multiple myeloma Tumor stroma communication Syntenin inhibition Secretome 
ProteomicsCharacterization of syntenin knockout exosomes from 4T1 murine breast cancer cells
Tumor cells are known to induce tumor-supporting phenotypes in surrounding stroma cells which leads to the creation of a favourable tumor niche and sustained growth as well as progression of the tumor. One mechanism how tumor cells can modulate surrounding stroma cells is through the release of extr...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2025-08-25 | PXD007721 | Pride
Breast cancer Syntenin Crispr/cas9 Exosomes 
TranscriptomicsMDA-9/Syntenin regulates differentiation and angiogenesis programs in Head and Neck Squamous Cell Carcinoma
We identified MDA-9/Syntenin (8q12) as a key component of HNSCC differentiation and angiogenesis. Robust reduction in the expression of cyclinD1, CDK4, CTNNB1, STAT3 and PI3K were evident in MDA- 9/Syntenein depleted cells, which was reversed following MDA-9/Syntenin overexpression in immortalized o...
ORGANISM(S): Homo sapiens 
2015-11-23 | GSE57760 | GEO
TranscriptomicsSyntenin-1 is expressed in uveal melanoma and correlates with metastatic progression
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, being at that time almost always fatal. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis...
ORGANISM(S): Homo sapiens 
2012-04-18 | GSE27831 | GEO
UnknownDownregulation of stromal syntenin sustains AML development.
Not available
S-EPMC10630886 | biostudies-literature
UnknownHeparanase activates the syndecan-syntenin-ALIX exosome pathway.
Not available
S-EPMC4387558 | biostudies-literature
UnknownSyntenin-knock out reduces exosome turnover and viral transduction.
Not available
S-EPMC7892569 | biostudies-literature
UnknownSyntenin, a PDZ protein that binds syndecan cytoplasmic domains.
Not available
S-EPMC28366 | biostudies-literature
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