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TranscriptomicsGenomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease
Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased 4 controls( beagle ...
ORGANISM(S): Canis lupus familiaris 
2008-05-15 | E-GEOD-11460 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity
This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...
ORGANISM(S): Mus musculus 
2018-07-13 | E-HCAD-18 | biostudies-arrayexpress
UnknownMyocardial Infarction Alters Adaptation of the Tethered Mitral Valve.
Not available
S-EPMC5099077 | biostudies-literature
ProteomicsIntegration of functional imaging, cytometry and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
Human Mitral valve (mv) Proteomic Ischemic mitral regurgitation (imr) Echocardiography Endothelial-to-mesenchymal transition (endmt) Histo-cytometry 
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine heart valves in all stages of Myxomatous mitral valve disease (Normal-4)
Whole mitral valves from each Whitney grade of disease; normal (n=6), grade 1 (n=5), grade 2 (n=6), grade 3 (n=6) and grade 4 (n=5). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was pe...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8618 | biostudies-arrayexpress
TranscriptomicsExpression data from Sus scrofa atria
Regulatory Mechanisms of Atrial Remodeling of Mitral Regurgitation Pigs This study enrolled 6 pigs (age: 18 months) and divided into three groups: mitral regurgitation pigs (MR) (n = 2; 2 males sacrificed 12 months after surgery), MR pigs treated with valsartan (MRV) (n = 2; 2 males age-matched to ...
ORGANISM(S): Sus scrofa 
2015-02-01 | E-GEOD-43072 | biostudies-arrayexpress
GenomicsmTOR signal in mitral valve diseases
mTOR signal in mitral valve diseases
PRJNA1247445 | ENA
GenomicsSingle-cell analysis reveals the loss of progenitor subpopulation of valvular endothelial cells leads to functional mitral regurgitation
Single-cell analysis reveals the loss of progenitor subpopulation of valvular endothelial cells leads to functional mitral regurgitation
PRJNA1010799 | ENA
GenomicsCellular composition of murine mitral valves during autoimmune valvular carditis
Cellular composition of murine mitral valves during autoimmune valvular carditis
PRJNA913174 | ENA
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
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