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TranscriptomicsGenomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease
Evaluation of global expression patterns provides a molecular portrait of mitral valve disease, yields insight into the pathophysiologic aspects of DMVD, and identifies intriguing genes and pathways for further study. (Am J Vet Res 2006;67:1307–1318) Keywords: control vs diseased 4 controls( beagle ...
ORGANISM(S): Canis lupus familiaris 
2008-05-15 | E-GEOD-11460 | biostudies-arrayexpress
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
ProteomicsSerum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially d...
ORGANISM(S): Bos taurus (Bovine) 
2023-05-10 | PXD038475 | Pride
Myxomatous mitral valve disease Degenerative mitral valve disease Tmt proteomics Dogs Serum 
ProteomicsMyocardial proteome profiling reveals disease- and sex-specific alterations in patients with aortic valve stenosis and mitral valve regurgitation
Heart valve diseases, such as aortic valve stenosis (AS) and mitral valve regurgitation (MR), are leading causes of heart failure. However, myocardial proteome studies in AS and MR are extremely rare. We profiled the proteome of 75 human left ventricular myocardial biopsies (AS=41, MR=17, controls=1...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD023800 | Pride
Mitral regurgitation Sex differences Cytoskeleton Aortic stenosis Fibrosis Energy metabolism Proteostasis Heart Extracellular matrix 
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine heart valves in all stages of Myxomatous mitral valve disease (Normal-4)
Whole mitral valves from each Whitney grade of disease; normal (n=6), grade 1 (n=5), grade 2 (n=6), grade 3 (n=6) and grade 4 (n=5). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was pe...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8618 | biostudies-arrayexpress
TranscriptomicsExpression analysis of human aortic valve interstitial cells (hAVICs), mitral valve interstitial cells(hMVICs) and dermal firbroblasts (hDFs)
Investigation of whole genome gene expression level changes in hAVICs and hMVICs, compared to human dermal fibroblasts. A three chip assay using total RNA obtained from primary cultured normal valve interstital cells and human dermal fibroblasts was performed. Each chip measures the expression level...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-40801 | biostudies-arrayexpress
ProteomicsIntegration of functional imaging, cytometry and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
Human Mitral valve (mv) Proteomic Ischemic mitral regurgitation (imr) Echocardiography Endothelial-to-mesenchymal transition (endmt) Histo-cytometry 
GenomicsmTOR signal in mitral valve diseases
mTOR signal in mitral valve diseases
PRJNA1247445 | ENA
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