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TranscriptomicsPrimate transcript and protein expression levels evolve under compensatory selection pressures
Variation in gene regulation is thought to have played an important role in the evolution of primates, and many studies have documented differences in mRNA expression levels across primate species. However, it is not yet known to what extent measurements of divergence in mRNA levels reflect divergen...
ORGANISM(S): Pan troglodytes 
2013-10-17 | E-GEOD-49682 | biostudies-arrayexpress
TranscriptomicsMycobacterial infection induces a specific human innate immune response
The innate immune system provides the first response to pathogen infection and orchestrates the activation of the adaptive immune system. Though a large component of the innate immune response is common to all infections, pathogen-specific innate immune responses have been documented as well. The in...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-67427 | biostudies-arrayexpress
OtherImpact of regulatory variation from RNA to protein
Data from ProteomeXchange, PXD ID: PXD001406. Experiment: GM18519, MSB14195, file: GM18519_MSB14195_16.mzml. Published as part of Science 2014 Dec. 18 . From the Abstract: {{i}} ... we mapped genetic variants that are associated with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs). ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210033257 | GPMDB
Resource Reanalysis 
OtherImpact of regulatory variation from RNA to protein
Data from ProteomeXchange, PXD ID: PXD001406. Experiment: GM19138, MSB14233, file: GM19138_MSB14233_29.mzml. Published as part of Science 2014 Dec. 18 . From the Abstract: {{i}} ... we mapped genetic variants that are associated with eQTLs, ribosome occupancy (rQTLs), or protein abundance (pQTLs). ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320005946 | GPMDB
Resource Reanalysis 
TranscriptomicsImpact of regulatory variation from mRNA to protein
Genetic variants that impact gene regulation are important contributors to human phenotypic variation. For this reason, considerable efforts have been made to identify genetic associations with differences in mRNA levels of nearby genes, namely, cis expression quantitative trait loci (eQTLs). The ph...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-61742 | biostudies-arrayexpress
TranscriptomicsGeneration of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics (methylation array)
Comparative studies in primates are extremely restricted because we only have access to a few types of cell lines from non-human apes and to a limited collection of frozen tissues. In order to gain better insight into regulatory processes that underlie variation in complex phenotypes, we must have a...
ORGANISM(S): Pan troglodytes 
2014-09-11 | E-GEOD-61342 | biostudies-arrayexpress
TranscriptomicsGeneration of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics (RNA-Seq)
Comparative studies in primates are extremely restricted because we only have access to a few types of cell lines from non-human apes and to a limited collection of frozen tissues. In order to gain better insight into regulatory processes that underlie variation in complex phenotypes, we must have a...
ORGANISM(S): Pan troglodytes 
2014-09-10 | E-GEOD-60996 | biostudies-arrayexpress
GenomicsGeneration of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics [ChIP-Seq]
Comparative genomics studies in primates are extremely restricted due to our limited access to samples from non-human apes. In order to gain better insight into the genetic processes that underlie variation in complex phenotypes in primates, we must have access to faithful model systems for a wide r...
ORGANISM(S): Pan troglodytes 
2015-06-17 | E-GEOD-69919 | biostudies-arrayexpress
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