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ProteomicsStructural dynamics of the chicken TRPV4 N-terminal domain
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an in...
ORGANISM(S): Escherichia coli Gallus gallus (Chicken) 
2023-10-24 | PXD041067 | Pride
Trpv4 
UnknownBackbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation.
Not available
S-EPMC9027025 | biostudies-literature
ProteomicsHierarchical antagonistic regulatory elements in the TRPV4 intrinsically disordered N-terminus modulate lipid binding and channel activity through transient long-range interactions
Intrinsically disordered regions (IDRs) are important for the functional regulation of membrane receptors. Among the TRP Vanilloid channels involved in thermo- and osmosensation, TRPV4 features the largest N-terminal IDR of ~150 residues. Here, we elucidate the structural ensemble of the TRPV4 IDR t...
ORGANISM(S): Gallus gallus (Chicken) 
2023-08-01 | PXD038153 | Pride
Trp channel Integrated structural biology Intrinsically disordered protein Long-range communication Pip2 binding 
UnknownCrosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity.
Not available
S-EPMC10344929 | biostudies-literature
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UnknownNeuroprotection by Flaxseed Oil in a Model of Hippocampal Injury Induced by Trimethyltin Involves Purinergic System Modulation.
Not available
S-EPMC12609297 | biostudies-literature
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