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GenomicsRECQL5 Controls Transcript Elongation and Suppresses Transcription-Associated Genome Instability
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49134 | biostudies-arrayexpress
TranscriptomicsSAGE libraries from cell bodies and axons of NGF-differentiated sympathetic neurons
The subcellular localization of specific mRNAs is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. In neurons, mRNA trafficking and local protein translation in dendrites provides an important mechanism that mediates synaptic ...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-13788 | biostudies-arrayexpress
GenomicsGenome wide profiling of RNA Polymerase II upon knock-down or overexpression of RECQL5
RECQL5 globally effects the distribution of RNA Polymerase II on genes in a dose dependent manner. Knock-down of RECQL5 reduces RNA Polymerase II density in the gene body, while increasing density on TSS and TTS. Overexpression shows exactly the opposite effect. We postulate that RECQL5 acts as a...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49008 | biostudies-arrayexpress
TranscriptomicsMapping of nascent RNA upon release of DRB in WT and KD of RECQL5
Global Run-On has been performed on WT or KD for RECQL5 cells after release from DRB. When RECQL5 is knocked-down the transcriptional wave front is more advanced, suggesting that transcription is faster. Constitutive knock-down cell lines expressing or not endogenous levels of shRNA resistant RECQL...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49133 | biostudies-arrayexpress
TranscriptomicsTiling path analysis to map chromatin anchors within the human Major Histocompatability Complex region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts
Mapping of chromatin anchors within the human Major Histocompatability Complex (MHC) region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts.
ORGANISM(S): Homo sapiens 
2008-10-01 | E-MEXP-1793 | biostudies-arrayexpress
TranscriptomicsIdentifying novel anti-angiogenic targets in human breast cancer
We analysed gene expression in normal breast blood vessels and breast invasive ductal carinoma blood vessels. Normal breast sections and IDC breast sections were immunostained for endothelial-specific CD31. Vessels were dissected and captured with laser capture microscopy, and RNA was extracted and ...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-31138 | biostudies-arrayexpress
GenomicsTracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy
Esophageal adenocarcinomas (EACs) are associated with dismal prognosis. Deciphering the evolutionary histories of this disease may shed light on therapeutically tractable targets and reveal changing mutational processes during the disease course and following neoadjuvant chemotherapy (NAC). We exome...
EGAS00001001254 | EGA
Genomicsena-DATASET-UCL-14-05-2015-18:11:37:007-120 - samples
This dataset contains whole exome data from 8 esophageal adenocarcinoma tumors, that has been subjected to multiregion sequencing, ranging from 3-8 regions per tumor. In total, 40 tumor samples and 8 normal blood samples have been sequenced on Illumina HiSeq 2500 at a median dept of 90x.
EGAD00001001364 | EGA
GenomicsTRACERx esophageal adenocarcinoma
Data Access Committee EGAC00001000340
EGAC00001000340 | EGA
Genomicsena-DATASET-SC-21-07-2014-10:55:39:527-89 - samples
NSCLC targeted.
EGAD00001000889 | EGA
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