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GenomicsSLAM-seq ML-792
SLAM-seq ML-792
PRJNA703953 | ENA
GenomicsMost cancer cell lines give very modest transcriptional regulation following treatment with the SUMO activating enzyme inhibitors TAK-981 or ML-792
Most cancer cell lines give very modest transcriptional regulation following treatment with the SUMO activating enzyme inhibitors TAK-981 or ML-792
PRJNA723843 | ENA
TranscriptomicsMost cancer cell lines give very modest transcriptional regulation following treatment with the SUMO activating enzyme inhibitors TAK-981 or ML-792
Modest transcriptional changes has been previously observed in solid tumor cell lines in response to inhibition of SUMOylation by ML-792 and here confirmed with TAK-981, lacking a robust induction of IFN1 genes. Comparable modulation of gene expression in HCT116, MDA-MB-231 and Colo-205 cells by TAK...
ORGANISM(S): Mus musculus Homo sapiens 
2021-04-23 | GSE173116 | GEO
UnknownEffects of targeting sumoylation processes during latent and induced Epstein-Barr virus infections using the small molecule inhibitor ML-792.
Not available
S-EPMC8136211 | biostudies-literature
ProteomicsSupercharging-Enhanced nDIA-MS Enables Global Profiling of Drug-Induced Proteome Solubility Shifts (solubility proteomics)
Mass spectrometry (MS)-based proteomics has become indispensable for high-throughput quantitation of protein expression. However, protein function is regulated by a variety of factors beyond abundance alone. Here, we optimized narrow-window, data-independent ac-quisition (nDIA) MS with 3% DMSO as a ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064185 | Pride
Ml-792 Proteome Solubility shift Mg132 
GenomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
RNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
PRJEB82977 | ENA
TranscriptomicsRNA-seq of mouse ME3 control and Irx3-KO cells on days -1, 1 and 9 of adipogenic differentiation after treatment with DMSO or the SUMOylation inhibitor ML-792
ME3 control and Irx3-KO mouse beige-like preadipocytes were grown in proliferation medium until confluence (day -2), before induction of adipogenesis on day 0 followed by adipogenic differentiation for 9 days. Cells were treated with either DMSO or 0.5 uM ML-792 for 24h either from day -2 to day -1 ...
ORGANISM(S): Mus musculus 
2025-05-17 | E-MTAB-14723 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
GenomicsRNA-seq of mouse ME3 control and Irx3-KO cells on days -1, 1 and 9 of adipogenic differentiation after treatment with DMSO or the SUMOylation inhibitor ML-792
RNA-seq of mouse ME3 control and Irx3-KO cells on days -1, 1 and 9 of adipogenic differentiation after treatment with DMSO or the SUMOylation inhibitor ML-792
PRJEB83826 | ENA
OtherSLAM-seq ML-792
Tight control of gene expression networks involved in adipose tissue formation and plasticity is required to adapt to energy needs and environmental cues. However, little is known about the mechanisms that orchestrate the dramatic transcriptional changes leading to adipocyte differentiation. We inve...
ORGANISM(S): Mus musculus 
2022-01-06 | GSE167221 | GEO
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