Mll - OmicsDI

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Genomics (1419)
Unknown (1410)
Transcriptomics (1068)
Proteomics (75)
Other (34)
Methylation profiling (15)
Metabolomics (12)
Clinical (10)
Genomic (2)
Multiomics (1)

Organisms

Homo sapiens (744)
Mus musculus (646)
Drosophila melanogaster (25)
Caenorhabditis elegans (15)
Arabidopsis thaliana (11)
Pseudomonas aeruginosa (7)
Saccharomyces cerevisiae (7)
Escherichia coli (6)
Schmidtea mediterranea (3)
Rhizobium leguminosarum (3)
Schizosaccharomyces pombe (3)
Trypanosoma brucei (3)
Neurospora crassa (2)
Medicago truncatula (2)
Bacillus subtilis (2)
Salmonella enterica subsp. enterica serovar Typhimurium (2)
Pseudomonas putida (2)
Pseudomonas aeruginosa PAO1 (2)
Cryptococcus neoformans (2)
Candida albicans (2)
Rhynchophorus phoenicis (1)
Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 (1)
plant metagenome (1)
Vitis x champinii x Vitis riparia (1)
Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74 (1)
Neurospora crassa OR74A (1)
Methanococcus maripaludis S2 (1)
Tetrahymena thermophila (1)
Streptococcus gordonii (1)
Rhodococcus aetherivorans (1)

Organisms

Homo sapiens (455)
Mus musculus (435)
Caenorhabditis elegans (9)
Macaca mulatta (1)
unidentified (1)

Repository

ENA (1062)
geo (842)
biostudies-arrayexpress (585)
pride (54)
EGA (46)
MassIVE (12)
MetaboLights (7)
jPOST (5)
ExpressionAtlas (4)
MetabolomicsWorkbench (3)
dbGaP (2)
GNPS (2)
iProX (2)
PeptideAtlas (2)
NODE (1)

Tissue

Cell culture (17)
Bone marrow (12)
Blood (7)
Stem cell (5)
Blood cell (5)
Embryonic stem cell (3)
Epithelial cell (3)
B cell (3)
Liver (3)
Cells (2)
HEK-293T cell (2)
JURKAT cell (2)
Macrophage (2)
Primary cell (2)
T cell (2)
Cultured cells (1)
Marrow (1)
Extracellular region (1)
Hematopoietic progenitor cell differentiation (1)
B-cell lymphoma/leukemia 11B (1)
Hematopoietic multipotent progenitor cell (1)
C2C12 cell (1)
Skeletal muscle myoblast (1)
Acute myeloid leukemia cell line (1)
Kidney medulla cell (1)
Leukocyte (1)
Cell suspension culture (1)
HeLa cell (1)
Whole body (1)
Erythrocyte (1)

Disease

Acute leukemia (17)
Burkitt Lymphoma (8)
Acute myeloid leukemia (5)
Normal (3)
Wilms tumour (2)
Breast cancer (2)
Lymphoblastic leukemia (1)
B-precursor acute lymphoblastic leukemia (1)
Prostate carcinoma lymph node metastasis (1)
Infant Acute Lymphoblastic Leukaemia (1)
Myeloid neoplasm (1)
Leukemic (1)
Precursor T lymphoblastic leukemia (1)
T-cell acute lymphoblastic leukemia (1)
Mixoid liposarcoma (1)
Embryonal carcinoma (1)
Primary Myelofibrosis (1)
Mycoses (1)
Niemann-Pick disease type C1 (1)
B-cell acute lymphoblastic leukemia (1)
Cachexia (1)
Adenocarcinoma (1)
Niemann-Pick disease (1)
Lymphoma (1)

Technology Type

Mass Spectrometry (57)
Shotgun proteomics (20)
Affinity purification coupled with mass spectrometry proteomics (17)
Bottom-up proteomics (8)
Data-dependent acquisition (7)
Mass spectrometry (5)
Data-independent acquisition (5)
Gel-based experiment (4)
ESI (3)
Mass spectrometry assay (2)
Illumina HiSeq 2000, Affymetrics_SNP_6.0-, Illumina Genome Analyzer IIx (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000 (1)
Illumina MiSeq (1)
MSE (1)
DiaPASEF (1)
SWATH MS (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (16)
Illumina HiSeq 2000 (11)
NextSeq 500 (9)
Illumina HiSeq 2500 (8)
Illumina HiSeq 4000 (7)
ScanArray [PerkinElmer] (4)
Axon- GenePix4000B (4)
Q Exactive (3)
ScanArray 6000 [Perkin Elmer] (2)
Illumina HiSeq X (2)
NextSeq 550 (2)
Q Exactive HF (2)
Illumina HiSeq 2000 platform (1)
NCounter Prep Station & Digital Analyzer (1)
NanoString (1)
TapeStation (1)
10x Chromium with a target of 5,000 cells. Chromium Single Cell 3’ Library & Gel Bead Kit v2 (1)
10X Genomics reagent kit (1)
Axon GenePix 4000B scanning hardware (1)
Illumina NovaSeq X (1)
NA (1)
N/A (1)
HiSeq X Ten (1)
Illumina MiSeq (1)
Illumina HiSeq 1500 (1)
Ion Chromatography Mass Spectrometer and QExactive HF-X Mass Spectrometer (1)
Orbitrap Fusion ETD (1)
LTQ Orbitrap Elite (1)
LTQ (1)
TripleTOF 5600 (1)

Publication Date

2016 (123)
2013 (109)
2015 (104)
2023 (103)
2022 (103)
2025 (99)
2014 (97)
2012 (94)
2021 (82)
2011 (82)
2019 (62)
2020 (62)
2017 (62)
2009 (54)
2024 (52)
2018 (52)
2008 (51)
2026 (43)
2010 (37)
2005 (13)
2007 (10)
2006 (10)
2004 (3)
2003 (1)

UNIPROT ID/AC

Q2HJ38 (2)
P01966 (2)
A5D989 (2)
Q5E9B5 (2)
P68103 (2)
P02769 (2)
P02668 (2)
Q0VCM5 (1)
P41541 (1)
Q3ZC89 (1)
Q3T0K2 (1)
Q58DS9 (1)
P62866 (1)
P04973 (1)
Q0II59 (1)
P48035 (1)
P10790 (1)
Q5E9A3 (1)
Q3SYZ4 (1)
Q3T0R7 (1)
Q3MHX5 (1)
Q2HJD7 (1)
Q29RZ0 (1)
Q0P5L8 (1)
P61286 (1)
P00921 (1)
A6QQF5 (1)
Q56JX5 (1)
O18789 (1)
P61603 (1)

ENSEMBL ID

ENSBTAG00000022004 (2)
ENSBTAG00000020757 (1)
ENSBTAG00000031279 (1)
ENSBTAP00000044884 (1)
ENSBTAG00000014423 (1)
ENSBTAG00000008570 (1)
ENSBTAG00000015980 (1)
ENSBTAG00000015438 (1)
ENSBTAG00000021580 (1)
ENSBTAG00000002507 (1)
ENSBTAG00000020527 (1)
ENSBTAG00000013953 (1)
ENSBTAG00000004230 (1)
ENSBTAG00000039684 (1)
ENSBTAG00000019915 (1)
ENSBTAG00000006045 (1)
ENSBTAG00000040295 (1)
ENSBTAG00000025868 (1)
ENSBTAG00000024663 (1)
ENSBTAG00000017970 (1)
ENSBTAG00000013527 (1)
ENSBTAG00000012586 (1)
ENSBTAG00000012490 (1)
ENSBTAG00000010799 (1)
ENSBTAG00000006898 (1)
ENSBTAG00000003758 (1)
ENSBTAG00000001601 (1)
ENSBTAG00000006263 (1)

CHEBI ID

CHEBI:83362 (1)
CHEBI:83361 (1)
CHEBI:83172 (1)
CHEBI:85595 (1)
CHEBI:85601 (1)
CHEBI:85600 (1)
CHEBI:85599 (1)
CHEBI:85626 (1)
CHEBI:85597 (1)
CHEBI:67082 (1)
CHEBI:67084 (1)
CHEBI:67085 (1)
CHEBI:85590 (1)
CHEBI:85588 (1)
CHEBI:85584 (1)
CHEBI:85583 (1)
CHEBI:85582 (1)
CHEBI:85570 (1)
CHEBI:72348 (1)
CHEBI:85574 (1)
CHEBI:67070 (1)
CHEBI:67071 (1)
CHEBI:67066 (1)
CHEBI:67067 (1)
CHEBI:67077 (1)
CHEBI:85568 (1)
CHEBI:85567 (1)
CHEBI:85566 (1)
CHEBI:85565 (1)
CHEBI:66967 (1)

Metabolite Name

4-O-Methylpinosylvic Acid (1)
Dg(15:0/18:2(9Z,12Z)/0:0) (1)
9-Hydroxynon-2-Enal (1)
Gpgro(14:0/14:0) (1)
(1Z,4Z)-1,5-Bis(4-Hydroxyphenyl)-1,4-Pentadiene (1)
Dg(18:3(6Z,9Z,12Z)/15:0/0:0) (1)
Gpgro(14:0/12:0) (1)
Dg(18:1(9Z)-O(12,13)/0:0/15:0) (1)
Gpgro(16:0/14:1) (1)
Gpgro(12:0/16:0) (1)
Gpgro(14:0/14:1) (1)
Tg(8:0/8:0/I-17:0) (1)
Dg(I-13:0/20:4(5Z,8Z,11Z,14Z)-Oh(17)/0:0) (1)
Gpgro(12:0/15:0) (1)
(S)-7-(3-Amino-1-Pyrrolidinyl)-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid (1)
(2S)-2-[6-(Sulfooxy)Naphthalen-2-Yl]Propanoic Acid (1)
5-8'-Benzofuran Dehydrodiferulic Acid (1)
Mesoxalic Acid (1)
Tg(8:0/8:0/15:0) (1)
(4As,5As,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12A-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboximidic Acid (1)
Pa(A-13:0/I-17:0) (1)
1,2-Dipalmitoyl-Sn-Glycerol 3-Phosphate (1)
Lpg(15:0)-D4 (1)
2,4-Dimethyladipic Acid (1)
(1Alpha,4Alpha,5Beta,6Alpha,11Betah)-1,4-Epoxy-5-Hydroxy-10(14)-Germacren-12,6-Olide (1)
Pa(18:1(12Z)-2Oh(9,10)/I-14:0) (1)
Fahfa(18:0/11-O-16:0) (1)
Gpa(18:2/18:2) (1)
2-[3-[4-(3-Chlorophenyl)Piperazin-1-Yl]-1-Hydroxypropyl]-5-Ethyl-4-(2-Phenoxyethyl)-1,2,4-Triazol-3-One (1)
4-{[(3S)-3-{[(7-Methoxynaphthalen-2-Yl)Sulfonyl](Methyl)Amino}-2-Oxopyrrolidin-1-Yl]Methyl}Thiophene-2-Carboximidamide (1)

First Public Date

2014 (161)
2023 (121)
2022 (105)
2025 (101)
2021 (88)
2019 (68)
2024 (63)
2020 (63)
2016 (55)
2015 (52)
2018 (50)
2017 (49)
2026 (48)
2013 (37)
2012 (1)

Study status

Completed (8)
Terminated (1)
Withdrawn (1)

Study type

Transcription profiling by array (297)
ChIP-seq (78)
RNA-seq of coding RNA (74)
ChIP-chip by tiling array (24)
Comparative genomic hybridization by array (16)
Methylation profiling by array (15)
RNA-seq of coding RNA from single cells (14)
Methylation profiling by high throughput sequencing (10)
ChIP-chip by array (7)
Other (7)
Unknown experiment type (4)
Transcription profiling by tiling array (4)
DNA-seq (4)
Genotyping by array (3)
RNA-seq of non coding RNA (3)
Animal - One-color microarray (2)
CLIP-Seq (2)
CUT&RUN (2)
Cell line - Methylation microarray (1)
RNA-seq of non coding RNA from single cells (1)
MeDIP-seq (1)
Human - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Human - One-color microarray (1)
Cell line - High-throughput sequencing (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
4C (1)
ATAC-seq (1)

Release Date

2021 (150)
2016 (144)
2015 (135)
2013 (131)
2022 (128)
2014 (126)
2023 (114)
2018 (106)
2024 (104)
2012 (104)
2019 (103)
2011 (98)
2020 (95)
2017 (82)
2025 (80)
2010 (71)
2009 (60)
2008 (55)
2026 (22)
2005 (20)
2007 (18)
2006 (12)
2001 (6)
2000 (6)
2004 (5)
1997 (5)
2003 (4)
1999 (4)
2002 (3)
1998 (3)

Lab affiliation

German Cancer Consortium (DKTK), partner site Freiburg German Cancer Research Center (DKFZ) Foundation under Public Law c/o Department of Urology Zentrale Klinische Forschung (ZKF) Medical Center-University of Freiburg Breisacher Str. 66, 79106 Freiburg, Germany (4)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University (2)
Department of pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China (2)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Lund Stem Cell Center, Division of Molecular Hematology, Lund University, Lund, Sweden (2)
Radboud University Nijmegen (1)
Head Proteomics Group Leiden University Medical Center Center for Proteomics and Metabolomics (1)
Cambridge Stem Cell Institute, Cambridge, United Kingdom, CB2 0AW (1)
Department of Chemistry, Yale University, New Haven, CT, USA (1)
Biological Chemistry, Chemistry and Biochemistry, UCLA,Los Angeles, California, USA (1)
Ludwig Boltzmann Institute Cancer Research, Vienna, Austria (1)
Shanghai Jiao Tong University Ming Yu Lab (1)
1 Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 2 Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA 3 Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710, USA 4 Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA (1)
School of Basic Medical Sciences, Chongqing Medical University, Chongging, China (1)
Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria. (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Core Facility Proteomics Hannover Medical School Carl-Neuberg-Str. 1 30625 Hannover Germany (1)
CECAD Research Center Institute for Genome Stability in Aging and Disease University of Cologne (1)
Lady Davis Institue for Medical Research, McGill University, Canada Department of Medicine, McGill University, Canada (1)
School of Basic Medical Sciences, Chongqing Medical Universityqing Medical Universityic Medical Sciences, Chongqing Medical University (1)
Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands. (1)
School of Basic Medical Sciences, Chongqing Medical University (1)
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester Cancer Research Centre Building, 555 Wilmslow Road, Manchester, M20 4GJ, United Kingdom (1)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University BMC B12, 221 84 Lund, Sweden (1)
Proteomic Hematology Department of Experimental Medical Science Lund Stem Cell Center, Lund University BMC B12, 22184 Lund, Sweden (1)
Proteomic Hematology, Division of Molecular Hematology, Lund Stem Cell Center, Lund University (1)
School of Medicine, University of Dundee, Dundee (1)
Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA (1)
Goethe-Universität Frankfurt, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, Frankfurt am Main, GERMANY (1)
Professor for Stem Cell Aging Faculty of Medicine Friedrich-Schiller-University Jena Erlanger Allee, 07747 Jena; Germany (1)

Location

United States (10)
Italy (2)
Germany (1)

Keyword

Mycophenolic Acid (5)
Fludarabine (5)
Fludarabine phosphate (5)
Tacrolimus (4)
Cyclosporine (4)
Cyclosporins (4)
Cyclophosphamide (3)
Methotrexate (2)
Deferasirox (1)
Transplantation (1)
Hematopoietic Stem Cell Transplantation (1)
Bortezomib (1)
Busulfan (1)
Vorinostat (1)
Methylprednisolone (1)
Methylprednisolone Acetate (1)
Methylprednisolone Hemisuccinate (1)
Prednisolone (1)
Prednisolone acetate (1)
Prednisolone hemisuccinate (1)
Prednisolone phosphate (1)

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MLL Fusion Proteins Preferentially Regulate a Small Set of Wild Type MLL Target Genes in the Leukemic Genome

MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...

ORGANISM(S): Mus musculus

2011-04-28 | E-GEOD-24794 | biostudies-arrayexpress

MLL regulated genes in LSK/CD48- hematopoietic stem cells

The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...

ORGANISM(S): Mus musculus

2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress

Genome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias

We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression. Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retr...

ORGANISM(S): Mus musculus

2013-04-03 | E-GEOD-43062 | biostudies-arrayexpress

Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cells

MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...

ORGANISM(S): Mus musculus

2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress

Expression data from a human MLL-AF6 positive AML cell line

The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...

ORGANISM(S): Homo sapiens

2013-04-03 | E-GEOD-43068 | biostudies-arrayexpress

Genotyping of human Infant ALL samples to detect MLL-cooperating aberrations

In this study we explored the genotype of Infant ALL to detect MLL-cooperating aberrations, hidden to conventional techniques. In order to limit further heterogeneity, we focused on patients carrying the t(4;11) translocation, the most frequent genetic abnormality in Infant ALL. Final aim was to get...

ORGANISM(S): Homo sapiens

2009-12-03 | E-TABM-511 | biostudies-arrayexpress

Protein Interactions of 7 MLL-fusion Proteins

MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL protein. While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain p...

ORGANISM(S): Homo sapiens (Human)

2018-05-25 | PXD009338 | Pride

Aberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)

We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...

ORGANISM(S): Homo sapiens

2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress

Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML

We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Re...

ORGANISM(S): Mus musculus

2012-02-22 | E-GEOD-34961 | biostudies-arrayexpress

Epigenetic profiling of hematopoietic stem cells and leukemia stem cells

The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...

ORGANISM(S): Mus musculus

2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress

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