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TranscriptomicsMLL Fusion Proteins Preferentially Regulate a Small Set of Wild Type MLL Target Genes in the Leukemic Genome
MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations encode chimeric MLL fusions that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is un...
ORGANISM(S): Mus musculus 
2011-04-28 | E-GEOD-24794 | biostudies-arrayexpress
TranscriptomicsMLL regulated genes in LSK/CD48- hematopoietic stem cells
The histone methyltransferase mixed lineage leukemia (MLL) is essential to maintain hematopoietic stem cells and is a leukemia protooncogene. Although Hox genes are well-characterized targets of MLL and MLL fusion oncoproteins, the range of Mll-regulated genes in normal hematopoietic cells remains u...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-47205 | biostudies-arrayexpress
GenomicsGenome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias
We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression. Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retr...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43062 | biostudies-arrayexpress
TranscriptomicsExpression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress
TranscriptomicsExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Re...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34961 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML
We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34959 | biostudies-arrayexpress
GenomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)
We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress
ProteomicsProteome analysis of affinity-purified protein co-precipitates
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
ORGANISM(S): Homo Sapiens (human) 
2021-08-31 | PXD027400 | JPOST Repository
GenomicsEpigenetic profiling of hematopoietic stem cells and leukemia stem cells
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress
GenomicsThe histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells (ChIP-Seq data)
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) potential. KDM1A acts at genomic loci bound by MLL-AF9 to sustain expression of the associated oncogenic program, thus preventing di...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36346 | biostudies-arrayexpress
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