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UnknownProspective phase II trial of first-line rituximab, methotrexate, and orelabrutinib (R-MO) in primary central nervous system lymphoma.
Not available
S-EPMC12041229 | biostudies-literature
ProteomicsA Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing
Novel modalities such as Proteolysis Targeting Chimera (PROTAC) and RNA interference (RNAi) have the ability to inadvertently alter the abundance of endogenous proteins. Currently available in vitro secondary pharmacology assays, which evaluate off-target binding or activity of small molecules, do ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024312 | Pride
Proteomic platform for off-target screening for protac or rnai 
UnknownComplete Chloroplast Genome Sequence of Malus hupehensis: Genome Structure, Comparative Analysis, and Phylogenetic Relationships.
Not available
S-EPMC6278565 | biostudies-literature
UnknownFresh and cryopreserved ovarian tissue from deceased young donors yields viable follicles.
Not available
S-EPMC8823279 | biostudies-literature
UnknownA non-lethal method to assess element content in the endangered Pinna nobilis.
Not available
S-EPMC8478926 | biostudies-literature
ProteomicsSILAC-based Quantitative Proteomic Analysis Unveiled the Arsenite-induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells
Humans are exposed to arsenic species through inhalation, ingestion and dermal contact, which may lead to skin, liver, and bladder cancers as well as cardiovascular and neurological diseases. The mechanisms underlying the cytotoxic and carcinogenic effects of arsenic species, however, remain incompl...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005646 | Pride
Mass spectrometry Arsenite Silac Oxidative stress Quantitative proteomics 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownAbbreviated dynamic total-body [<sup>18</sup>F]FDG PET/CT protocols for predicting response in locally advanced non-small cell lung cancer via Patlak-Ki analysis.
Not available
S-EPMC12682553 | biostudies-literature
UnknownRadiosynthesis and in vivo evaluation of a novel σ1 selective PET ligand.
Not available
S-EPMC4288033 | biostudies-literature
UnknownThe complete chloroplast genome sequence of Malus prattii (Rosaceae) and its phylogenetic analysis.
Not available
S-EPMC7687563 | biostudies-literature
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