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MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
TranscriptomicsDifferential gene expression in roots of tcp9 and tcp20 mutants of Arabidopsis thaliana upon Heterodera schachtii infection as measured by RNAseq
We compared the gene expression of wild-type Col-0, tcp9, tcp20, and the double mutant tcp9tcp20. We either infected or mock-infected the plants with the beet cyst nematode Heterodera schachtii and measured the root transcriptome after 24, 48, and 72 hours post infection using RNA-seq. The aim of th...
ORGANISM(S): Arabidopsis thaliana 
2022-09-09 | E-MTAB-11649 | biostudies-arrayexpress
TranscriptomicsGene expression signature-based screening identifies new broadly effective influenza antivirals
Classical antiviral therapy inhibit viral proteins and are subject to resistance. To counteract this emergence, alternative strategy has been developed that target cellular factors. We hypothesized that such approach could also be useful to identify broad antivirals. Influenza A virus was used as a ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-22319 | biostudies-arrayexpress
MetabolomicsHost-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Animals and their associated microbiota share long evolutionary histories. However, it is not always clear how host genotype and microbiota interact to affect phenotype. We applied a hologenomic approach to explore how host-microbiota interactions shape lifetime growth and parasite infection in f...

2024-01-24 | MTBLS8575 | MetaboLights
TranscriptomicsHuman rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects
Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. Objective: To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic and healthy nasal epithelial cells (...
ORGANISM(S): Homo sapiens 
2014-07-28 | E-GEOD-52074 | biostudies-arrayexpress
UnknownSystemic administration of strontium or NBD peptide ameliorates early stage cartilage degradation of mouse mandibular condyles.
Not available
S-EPMC4695290 | biostudies-literature
UnknownA novel synthetic nucleic acid mixture for quantification of microbes by mNGS.
Not available
S-EPMC10926700 | biostudies-literature
UnknownGenome-wide identification and characterization of Fusarium circinatum-responsive lncRNAs in Pinus radiata.
Not available
S-EPMC8908662 | biostudies-literature
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