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GenomicsDistribution of Drosophila insulator proteins Mod(mdg4) and L(3)mbt in Kc cells
Here we map the localization of Mod(mdg4), including Mod(mdg4)2.2 specific and Mod(mdg4) common to all isoforms, to chromatin insulators, as well as the lethal-3 malignant brain tumor protein in Drosophila Kc cells. examination of genomic occupancy for Mod(mdg4)2.2, Mod(mdg4)BTB (all isoforms), and ...
ORGANISM(S): Drosophila melanogaster 
2012-06-18 | E-GEOD-36393 | biostudies-arrayexpress
Genomicsmod(mdg4)_W3L-seq
modENCODE_submission_4094 This submission comes from a modENCODE project of Kevin White. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The White Lab is aiming to map the association of many of the non-histone chromosomal proteins on the genome of Drosophila me...
ORGANISM(S): Drosophila melanogaster 
2013-08-28 | E-GEOD-50348 | biostudies-arrayexpress
TranscriptomicsVariable D. melanogaster Y chromosomes into the genetic background JIL-1/+, Mod(mdg4)/+, and Su(var)205/+.
Fly strains were obtained from the Bloomington Stock Center. The chromosomes containing the gene deletion mod(mdg4)L3101 {y[1] w[1118]; P{w[+mC]=lacW}mod(mdg4)[L3101]/TM3, Ser[1]}, HP1 {In(1)w[m4h]; Su(var)205[5]/In(2L)Cy,In(2R)Cy, Cy[1]}, mod(mdg4)G16853 {w[1118]; P{w[+mC]=EP}mod(mdg4)[G16853]/TM6C...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-46313 | biostudies-arrayexpress
GenomicsMod(mdg4) variants repress telomeric retrotransposon Het-A by blocking subtelomeric enhancers
Mod(mdg4) variants repress telomeric retrotransposon Het-A by blocking subtelomeric enhancers
PRJNA735251 | ENA
ProteomicsMultiple intron motifs have redundant functions in trans-splicing of the mod(mdg4) locus
In contrast to canonical cis-splicing, trans-splicing combines exons from two distinct transcripts, yielding chimeric mRNAs. One striking example is the ubiquitously expressed modifier of mdg4 (mod(mdg4)) locus in Drosophila, where all mRNAs spanning over 30 isoforms are generated exclusively by tra...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-05-28 | PXD079014 | Pride
Rna motifs Alternative splicing Spliceosome Rna-binding proteins Trans-splicing Mod(mdg4) Drosophila melanogaster 
GenomicsThe RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner
Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in different species implicates RNA and RNA-binding proteins as regulators of chromatin insulator activ...
ORGANISM(S): Drosophila melanogaster 
2014-04-18 | E-GEOD-51462 | biostudies-arrayexpress
GenomicsDistribution of Drosophila insulator proteins Mod(mdg4) and L(3)mbt in Kc cells
Here we map the localization of Mod(mdg4), including Mod(mdg4)2.2 specific and Mod(mdg4) common to all isoforms, to chromatin insulators, as well as the lethal-3 malignant brain tumor protein in Drosophila Kc cells.
ORGANISM(S): Drosophila melanogaster 
2012-06-18 | GSE36393 | GEO
TranscriptomicsMod(mdg4) variants repress telomeric retrotransposon Het-A by blocking subtelomeric enhancers
Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: Het-A, TART, TAHRE. Although their expression is highly dynamic, molecular mechanism governing these retrotransposons is poorly understood. Here, we show that specific splice variants of Mod(mdg4) act as repressors of Het-A...
ORGANISM(S): Drosophila melanogaster 
2022-10-20 | GSE176196 | GEO
GenomicsComparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of Snr1 or mod(mdg4) genes
Comparison of Drosophila melanogaster ovarian transcriptome after germline specific knock down of Snr1 or mod(mdg4) genes
PRJNA729042 | ENA
UnknownMod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.
Not available
S-EPMC9723646 | biostudies-literature
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