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GenomicsGenome wide promoter methylation analysis of mouse macrophages and endothelial cells isolated from ischemic hindlimbs using RRBS sequencing
Purpose: The goal of this study was to compare the genome-wide promoter methylation alterations in macrophages and endothelial cells during hindlimb ischemia among normal, hyperlipidemic and type-2 diabetic mice. Methods: Unilateral hindlimb ischemia was induced by ligating femoral artery proximal t...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-65759 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis seedlings mutant for essp3 and brm
Synthesis and accumulation of seed storage proteins (SSPs) is an important aspect of the seed maturation program. Genes encoding SSPs are specifically and highly expressed in the seed during maturation. However, the mechanisms that repress the expression of these genes in leaf tissue are not well un...
ORGANISM(S): Arabidopsis thaliana 
2009-02-07 | E-GEOD-11505 | biostudies-arrayexpress
ProteomicsEndogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here we show that UB...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD061852 | Pride
Stress granules Retrotransposon-derived proteins Ubiquilins 
TranscriptomicsE-IMBB-Mm-1
Transcription profiling of mouse livers in adult males and embryos with wild-type and TAF10 -/- hepatocytes.
ORGANISM(S): Mus musculus 
2008-11-08 | E-MTAB-3 | biostudies-arrayexpress
TranscriptomicsExpression profiling of patients with extreme corneal thinning and fragility
Extreme corneal fragility and thinning, with a high risk of catastrophic corneal rupture secondary to minimal trauma, is the major feature of brittle cornea syndrome (BCS). Expression profiling was performed with microarrays on fibroblasts from two individuals with BCS and two age and sex matched co...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-MEXP-3077 | biostudies-arrayexpress
GenomicsGenome wide DNA methylation sequencing of ischemic skeletal muscle from normal, hyperlipidemic and type 2 diabetic mice
Objective: To define the role of epigenetics, particularly DNA methylation in adaptive vascular growth in hyperlipidemic and type 2 diabetic mouse models of hind limb ischemia Methods: Unilateral hindlimb ischemia was induced by ligating femoral artery proximal to the bifurcation of superficial and ...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-42092 | biostudies-arrayexpress
MetabolomicsMMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA), is central in driving ferroptosis. Here, we reveal that ...

2023-09-06 | MTBLS8280 | MetaboLights
UnknownBimodal distribution of glucose is not universally useful for diagnosing diabetes.
Not available
S-EPMC2646016 | biostudies-literature
UnknownScaling up Kangaroo Mother Care in Ethiopia and India: a multi-site implementation research study.
Not available
S-EPMC8438727 | biostudies-literature
UnknownThe GenomeAsia 100K Project enables genetic discoveries across Asia.
Not available
S-EPMC7054211 | biostudies-literature
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